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Target Report Card

Target Name and Classification

Target ID CHEMBL6116
Preferred Name Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Synonyms LEM6 | Ligand effect modulator 6 | PGC-1-alpha | PGC1 | PGC1A | PPAR-gamma coactivator 1-alpha | PPARGC-1-alpha | PPARGC1 | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha SINGLE PROTEIN Q9UBK2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109819
Ensembl ENSG00000109819
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005665 (DNA-directed RNA polymerase II, core complex)
GO:0005719 (nuclear euchromatin)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016605 (PML body)
GO:0022626 (cytosolic ribosome)
GO:0043025 (neuronal cell body)
GO:0097440 (apical dendrite)
GO:1990843 (subsarcolemmal mitochondrion)
GO:1990844 (interfibrillar mitochondrion)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001104 (RNA polymerase II transcription cofactor activity)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003713 (transcription coactivator activity)
GO:0003723 (RNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016922 (ligand-dependent nuclear receptor binding)
GO:0030331 (estrogen receptor binding)
GO:0030374 (ligand-dependent nuclear receptor transcription coactivator activity)
GO:0031490 (chromatin DNA binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042975 (peroxisome proliferator activated receptor binding)
GO:0043014 (alpha-tubulin binding)
GO:0043565 (sequence-specific DNA binding)
GO:0050681 (androgen receptor binding)
GO:1990841 (promoter-specific chromatin binding)
GO Biological Process GO:0000302 (response to reactive oxygen species)
GO:0000422 (mitophagy)
GO:0001659 (temperature homeostasis)
GO:0001666 (response to hypoxia)
GO:0001678 (cellular glucose homeostasis)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0002021 (response to dietary excess)
GO:0002931 (response to ischemia)
GO:0006012 (galactose metabolic process)
GO:0006094 (gluconeogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006397 (mRNA processing)
GO:0006461 (protein complex assembly)
GO:0007005 (mitochondrion organization)
GO:0007329 (positive regulation of transcription from RNA polymerase II promoter by pheromones)
GO:0007568 (aging)
GO:0007586 (digestion)
GO:0007623 (circadian rhythm)
GO:0008209 (androgen metabolic process)
GO:0008380 (RNA splicing)
GO:0009409 (response to cold)
GO:0009750 (response to fructose)
GO:0010822 (positive regulation of mitochondrion organization)
GO:0014070 (response to organic cyclic compound)
GO:0014732 (skeletal muscle atrophy)
GO:0014823 (response to activity)
GO:0014850 (response to muscle activity)
GO:0014878 (response to electrical stimulus involved in regulation of muscle adaptation)
GO:0014912 (negative regulation of smooth muscle cell migration)
GO:0019395 (fatty acid oxidation)
GO:0021549 (cerebellum development)
GO:0022904 (respiratory electron transport chain)
GO:0030521 (androgen receptor signaling pathway)
GO:0030900 (forebrain development)
GO:0031325 (positive regulation of cellular metabolic process)
GO:0031667 (response to nutrient levels)
GO:0032922 (circadian regulation of gene expression)
GO:0034599 (cellular response to oxidative stress)
GO:0035066 (positive regulation of histone acetylation)
GO:0035865 (cellular response to potassium ion)
GO:0036273 (response to statin)
GO:0042493 (response to drug)
GO:0042594 (response to starvation)
GO:0042752 (regulation of circadian rhythm)
GO:0043201 (response to leucine)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045333 (cellular respiration)
GO:0045722 (positive regulation of gluconeogenesis)
GO:0045820 (negative regulation of glycolytic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046321 (positive regulation of fatty acid oxidation)
GO:0048511 (rhythmic process)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0050821 (protein stabilization)
GO:0050873 (brown fat cell differentiation)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051552 (flavone metabolic process)
GO:0051602 (response to electrical stimulus)
GO:0060612 (adipose tissue development)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071250 (cellular response to nitrite)
GO:0071313 (cellular response to caffeine)
GO:0071332 (cellular response to fructose stimulus)
GO:0071333 (cellular response to glucose stimulus)
GO:0071354 (cellular response to interleukin-6)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071372 (cellular response to follicle-stimulating hormone stimulus)
GO:0071392 (cellular response to estradiol stimulus)
GO:0071398 (cellular response to fatty acid)
GO:0071456 (cellular response to hypoxia)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0071871 (response to epinephrine)
GO:0071873 (response to norepinephrine)
GO:0090258 (negative regulation of mitochondrial fission)
GO:0097066 (response to thyroid hormone)
GO:0097067 (cellular response to thyroid hormone stimulus)
GO:1901215 (negative regulation of neuron death)
GO:1901558 (response to metformin)
GO:1901857 (positive regulation of cellular respiration)
GO:1901860 (positive regulation of mitochondrial DNA metabolic process)
GO:1901863 (positive regulation of muscle tissue development)
GO:1904635 (positive regulation of glomerular visceral epithelial cell apoptotic process)
GO:1904637 (cellular response to ionomycin)
GO:1904639 (cellular response to resveratrol)
GO:1904640 (response to methionine)
GO:1990845 (adaptive thermogenesis)
GO:2000184 (positive regulation of progesterone biosynthetic process)
GO:2000272 (negative regulation of receptor activity)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)
GO:2000507 (positive regulation of energy homeostasis)
GO:2001171 (positive regulation of ATP biosynthetic process)
Wikipedia PPARGC1A

Target Cross References - Protein

Human Protein Atlas ENSG00000109819
IntAct Q9UBK2
Open Targets ENSG00000109819
PharmGKB PA33558
Reactome R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-2151209 (Activation of PPARGC1A (PGC-1alpha) by phosphorylation.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-400253 (Circadian Clock.)
UniProt B7Z406 G8DM16 I3RTT5 I3RTT6 I3RTT7 I3RTT8 I3RTT9 Q3LIG1 Q4W5M7 Q9UBK2 Q9UN32

Target Cross References - Domain

InterPro IPR000504 (RRM_dom.)
IPR012677 (Nucleotide-bd_a/b_plait.)
Pfam PF00076 (RRM_1)

Target Cross References - Structure

PDBe 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4
CREDO 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4