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Target Report Card

Target Name and Classification

Target ID CHEMBL6115
Target Type SINGLE PROTEIN
Preferred Name Lysosomal protective protein
Synonyms CTSA | Carboxypeptidase C | Carboxypeptidase L | Cathepsin A | Lysosomal protective protein 20 kDa chain | Lysosomal protective protein 32 kDa chain | Lysosomal protective protein | PPCA | PPGB | Protective protein cathepsin A | Protective protein for beta-galactosidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s10 family

Target Components

Component Description Relationship Accession
Lysosomal protective protein SINGLE PROTEIN P10619

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000064601
Ensembl ENSG00000064601
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005764 (lysosome)
GO:0005783 (endoplasmic reticulum)
GO:0016020 (membrane)
GO:0043202 (lysosomal lumen)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO:0098575 (lumenal side of lysosomal membrane)
GO Molecular Function GO:0004180 (carboxypeptidase activity)
GO:0004185 (serine-type carboxypeptidase activity)
GO:0004308 (exo-alpha-sialidase activity)
GO:0008047 (enzyme activator activity)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0006687 (glycosphingolipid metabolic process)
GO:0006886 (intracellular protein transport)
GO:0031647 (regulation of protein stability)
GO:0043085 (positive regulation of catalytic activity)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0061684 (chaperone-mediated autophagy)
GO:1904714 (regulation of chaperone-mediated autophagy)
Wikipedia Cathepsin_A

Target Cross References - Protein

canSAR P10619
CGD Galactosialidosis
Human Protein Atlas ENSG00000064601
IntAct P10619
Guide to Pharmacology 1581
Open Targets ENSG00000064601
PharmGKB PA33572
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-4085001 (Sialic acid metabolism.)
UniProt B2R798 P10619 Q561W6 Q5JZH1 Q96KJ2 Q9BR08 Q9BW68

Target Cross References - Domain

InterPro IPR001563 (Peptidase_S10.)
IPR018202 (Ser_caboxypep_ser_AS.)
IPR029058 (AB_hydrolase.)
IPR033124 (Ser_caboxypep_his_AS.)
Pfam PF00450 (Peptidase_S10)

Target Cross References - Structure

PDBe 1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT
CREDO 1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT
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