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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6111
Target Type SINGLE PROTEIN
Preferred Name Protein-arginine deiminase type-4
Synonyms HL-60 PAD | PAD4 | PADI4 | PADI5 | PDI5 | Peptidylarginine deiminase IV | Protein-arginine deiminase type IV | Protein-arginine deiminase type-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Protein-arginine deiminase type-4 SINGLE PROTEIN Q9UM07

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000159339 ENSG00000280908
Ensembl ENSG00000159339 ENSG00000280908
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004668 (protein-arginine deiminase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016990 (arginine deiminase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002376 (immune system process)
GO:0006325 (chromatin organization)
GO:0006334 (nucleosome assembly)
GO:0006338 (chromatin remodeling)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006464 (cellular protein modification process)
GO:0016568 (chromatin modification)
GO:0018101 (protein citrullination)
GO:0019827 (stem cell population maintenance)
GO:0036413 (histone H3-R26 citrullination)
GO:0036414 (histone citrullination)
GO:0045087 (innate immune response)
Wikipedia PADI4

Target Cross References - Protein

canSAR Q9UM07
Human Protein Atlas ENSG00000159339 ENSG00000280908
IntAct Q9UM07
Guide to Pharmacology 2877
Open Targets ENSG00000159339 ENSG00000280908
PharmGKB PA32903
Reactome R-HSA-3247509 (Chromatin modifying enzymes.)
UniProt A8K392 B2RBW0 Q5VTZ8 Q70SX4 Q9UM07

Target Cross References - Domain

InterPro IPR004303 (PAD.)
IPR008972 (Cupredoxin.)
IPR013530 (PAD_C.)
IPR013732 (PAD_N.)
IPR013733 (Prot_Arg_deaminase_cen_dom.)
Pfam PF03068 (PAD)
PF08526 (PAD_N)
PF08527 (PAD_M)

Target Cross References - Structure

PDBe 1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G
CREDO 1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G
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