ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL6103
Preferred Name Transcription factor Sp1
Synonyms SP1 | TSFP1 | Transcription factor Sp1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Transcription factor Sp1 SINGLE PROTEIN P08047

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000185591
Ensembl ENSG00000185591
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0032993 (protein-DNA complex)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000982 (transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001046 (core promoter sequence-specific DNA binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008134 (transcription factor binding)
GO:0035035 (histone acetyltransferase binding)
GO:0042803 (protein homodimerization activity)
GO:0042826 (histone deacetylase binding)
GO:0043425 (bHLH transcription factor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0071837 (HMG box domain binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0016032 (viral process)
GO:0042795 (snRNA transcription from RNA polymerase II promoter)
GO:0043923 (positive regulation by host of viral transcription)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0100057 (regulation of phenotypic switching by transcription from RNA polymerase II promoter)
GO:1904828 (positive regulation of hydrogen sulfide biosynthetic process)
Wikipedia Sp1_transcription_factor

Target Cross References - Protein

canSAR P08047
Human Protein Atlas ENSG00000185591
IntAct P08047
Open Targets ENSG00000185591
PharmGKB PA36042
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2173796 (SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-2559585 (Oncogene Induced Senescence.)
R-HSA-6807505 (RNA polymerase II transcribes snRNA genes.)
UniProt E4Z9M7 G5E9M8 P08047 Q86TN8 Q9H3Q5 Q9NR51 Q9NY21 Q9NYE7

Target Cross References - Domain

InterPro IPR007087 (Znf_C2H2.)
IPR013087 (Znf_C2H2/integrase_DNA-bd.)
IPR015880 (Znf_C2H2-like.)
Pfam PF00096 (zf-C2H2)