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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6101
Target Type SINGLE PROTEIN
Preferred Name Signal transducer and activator of transcription 1-alpha/beta
Synonyms STAT1 | Signal transducer and activator of transcription 1-alpha/beta | Transcription factor ISGF-3 components p91/p84
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Signal transducer and activator of transcription 1-alpha/beta SINGLE PROTEIN P42224

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115415
Ensembl ENSG00000115415
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005829 (cytosol)
GO Molecular Function GO:0000979 (RNA polymerase II core promoter sequence-specific DNA binding)
GO:0000983 (RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity)
GO:0004871 (signal transducer activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO Biological Process GO:0006355 (regulation of transcription, DNA-dependent)
GO:0006919 (activation of caspase activity)
GO:0007249 (I-kappaB kinase/NF-kappaB cascade)
GO:0007260 (tyrosine phosphorylation of STAT protein)
GO:0009615 (response to virus)
GO:0044419 (interspecies interaction between organisms)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0060334 (regulation of interferon-gamma-mediated signaling pathway)
GO:0060337 (type I interferon-mediated signaling pathway)
GO:0060338 (regulation of type I interferon-mediated signaling pathway)
Wikipedia STAT1

Target Cross References - Protein

canSAR P42224
CGD Familial Candiasis, 7; STAT1 deficiency; Mycobacterial infection, atypical, familial disseminated
Human Protein Atlas ENSG00000115415
IntAct P42224
PharmGKB PA36183
Reactome REACT_16888 (Signaling by PDGF.)
REACT_6900 (Signaling in Immune system.)
UniProt A8K989 B2RCA0 D2KFR8 D3DPI7 P42224 Q53S88 Q53XW4 Q68D00 Q9UDL5

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001217 (STAT_TF_core.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011992 (EF-hand-like_dom.)
IPR012345 (STAT_TF_DNA-bd_sub.)
IPR013799 (STAT_TF_prot_interaction.)
IPR013800 (STAT_TF_alpha.)
IPR013801 (STAT_TF_DNA-bd.)
IPR015988 (STAT_TF_coiled-coil.)
IPR022752 (STAT1_TAZ2-bd_C.)
Pfam PF00017 (SH2)
PF01017 (STAT_alpha)
PF02864 (STAT_bind)
PF02865 (STAT_int)
PF12162 (STAT1_TAZ2bind)

Target Cross References - Structure

PDBe 1BF5 1YVL
CREDO 1BF5 1YVL
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