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Target Report Card

Target Name and Classification

Target ID CHEMBL6101
Preferred Name Signal transducer and activator of transcription 1-alpha/beta
Synonyms STAT1 | Signal transducer and activator of transcription 1-alpha/beta | Transcription factor ISGF-3 components p91/p84
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Signal transducer and activator of transcription 1-alpha/beta SINGLE PROTEIN P42224

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115415
Ensembl ENSG00000115415
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032991 (macromolecular complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000979 (RNA polymerase II core promoter sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0000982 (transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0000983 (transcription factor activity, RNA polymerase II core promoter sequence-specific)
GO:0001047 (core promoter binding)
GO:0003677 (DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004871 (signal transducer activity)
GO:0005164 (tumor necrosis factor receptor binding)
GO:0005515 (protein binding)
GO:0019899 (enzyme binding)
GO:0031730 (CCR5 chemokine receptor binding)
GO:0035035 (histone acetyltransferase binding)
GO:0035257 (nuclear hormone receptor binding)
GO:0042393 (histone binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0044389 (ubiquitin-like protein ligase binding)
GO:0045296 (cadherin binding)
GO:0051721 (protein phosphatase 2A binding)
GO:0070491 (repressing transcription factor binding)
GO:1990841 (promoter-specific chromatin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001937 (negative regulation of endothelial cell proliferation)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0002230 (positive regulation of defense response to virus by host)
GO:0003340 (negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0007221 (positive regulation of transcription of Notch receptor target)
GO:0007259 (JAK-STAT cascade)
GO:0007584 (response to nutrient)
GO:0008015 (blood circulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0009612 (response to mechanical stimulus)
GO:0010742 (macrophage derived foam cell differentiation)
GO:0014070 (response to organic cyclic compound)
GO:0016032 (viral process)
GO:0016525 (negative regulation of angiogenesis)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0032727 (positive regulation of interferon-alpha production)
GO:0032869 (cellular response to insulin stimulus)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034097 (response to cytokine)
GO:0035456 (response to interferon-beta)
GO:0035458 (cellular response to interferon-beta)
GO:0038114 (interleukin-21-mediated signaling pathway)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042981 (regulation of apoptotic process)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043434 (response to peptide hormone)
GO:0043542 (endothelial cell migration)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046725 (negative regulation by virus of viral protein levels in host cell)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051591 (response to cAMP)
GO:0051607 (defense response to virus)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0060334 (regulation of interferon-gamma-mediated signaling pathway)
GO:0060337 (type I interferon signaling pathway)
GO:0060338 (regulation of type I interferon-mediated signaling pathway)
GO:0061326 (renal tubule development)
GO:0070102 (interleukin-6-mediated signaling pathway)
GO:0070106 (interleukin-27-mediated signaling pathway)
GO:0070757 (interleukin-35-mediated signaling pathway)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071346 (cellular response to interferon-gamma)
GO:0071407 (cellular response to organic cyclic compound)
GO:0072136 (metanephric mesenchymal cell proliferation involved in metanephros development)
GO:0072162 (metanephric mesenchymal cell differentiation)
GO:0072308 (negative regulation of metanephric nephron tubule epithelial cell differentiation)
Wikipedia STAT1

Target Cross References - Protein

canSAR P42224
CGD Familial Candiasis, 7; STAT1 deficiency; Mycobacterial infection, atypical, familial disseminated
Human Protein Atlas ENSG00000115415
IntAct P42224
Open Targets ENSG00000115415
PharmGKB PA36183
Reactome R-HSA-1059683 (Interleukin-6 signaling.)
R-HSA-1169408 (ISG15 antiviral mechanism.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1839117 (Signaling by cytosolic FGFR1 fusion mutants.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-877300 (Interferon gamma signaling.)
R-HSA-877312 (Regulation of IFNG signaling.)
R-HSA-8854691 (Interleukin-20 family signaling.)
R-HSA-8939902 (Regulation of RUNX2 expression and activity.)
R-HSA-8984722 (Interleukin-35 Signalling.)
R-HSA-9013508 (NOTCH3 Intracellular Domain Regulates Transcription.)
R-HSA-9020956 (Interleukin-27 signaling.)
R-HSA-9020958 (Interleukin-21 signaling.)
R-HSA-909733 (Interferon alpha/beta signaling.)
R-HSA-912694 (Regulation of IFNA signaling.)
R-HSA-982772 (Growth hormone receptor signaling.)
UniProt A8K989 B2RCA0 D2KFR8 D3DPI7 P42224 Q53S88 Q53XW4 Q68D00 Q9UDL5

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001217 (STAT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR012345 (STAT_TF_DNA-bd_N.)
IPR013799 (STAT_TF_prot_interaction.)
IPR013800 (STAT_TF_alpha.)
IPR013801 (STAT_TF_DNA-bd.)
IPR015988 (STAT_TF_coiled-coil.)
IPR022752 (STAT1_TAZ2-bd_C.)
IPR035859 (STAT1_SH2.)
IPR036535 (STAT_N_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF01017 (STAT_alpha)
PF02864 (STAT_bind)
PF02865 (STAT_int)
PF12162 (STAT1_TAZ2bind)

Target Cross References - Structure