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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6097
Preferred Name Fatty acid desaturase 2
Synonyms Acyl-CoA 6-desaturase | D6D | Delta(6) desaturase | Delta(6) fatty acid desaturase | Delta-6 desaturase | FADS2 | Fatty acid desaturase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Fatty acid desaturase 2 SINGLE PROTEIN O95864

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134824
Ensembl ENSG00000134824
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004768 (stearoyl-CoA 9-desaturase activity)
GO:0016213 (linoleoyl-CoA desaturase activity)
GO:0016491 (oxidoreductase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006636 (unsaturated fatty acid biosynthetic process)
GO:0036109 (alpha-linolenic acid metabolic process)
GO:0043651 (linoleic acid metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia FADS2

Target Cross References - Protein

canSAR O95864
Human Protein Atlas ENSG00000134824
IntAct O95864
Open Targets ENSG00000134824
PharmGKB PA27974
Reactome R-HSA-2046105 (Linoleic acid (LA) metabolism.)
R-HSA-2046106 (alpha-linolenic acid (ALA) metabolism.)
UniProt A8K2M6 B7Z634 O95864 Q6MZQ7 Q96H07 Q96SV8 Q9H3G3 Q9Y3X4

Target Cross References - Domain

InterPro IPR001199 (Cyt_B5-like_heme/steroid-bd.)
IPR005804 (FA_desaturase_dom.)
IPR012171 (Fatty_acid_desaturase.)
Pfam PF00173 (Cyt-b5)
PF00487 (FA_desaturase)