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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6094
Target Type SINGLE PROTEIN
Preferred Name Ras-related C3 botulinum toxin substrate 1
Synonyms Cell migration-inducing gene 5 protein | RAC1 | Ras-like protein TC25 | Ras-related C3 botulinum toxin substrate 1 | TC25 | p21-Rac1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Ras-related C3 botulinum toxin substrate 1 SINGLE PROTEIN P63000

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301397 Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000136238
Ensembl ENSG00000136238
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0042470 (melanosome)
GO Molecular Function GO:0003924 (GTPase activity)
GO:0005525 (GTP binding)
GO:0030742 (GTP-dependent protein binding)
GO:0031996 (thioesterase binding)
GO Biological Process GO:0006915 (apoptosis)
GO:0006954 (inflammatory response)
GO:0007160 (cell-matrix adhesion)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007411 (axon guidance)
GO:0008624 (induction of apoptosis by extracellular signals)
GO:0010310 (regulation of hydrogen peroxide metabolic process)
GO:0010592 (positive regulation of lamellipodium assembly)
GO:0016032 (viral reproduction)
GO:0030032 (lamellipodium assembly)
GO:0030041 (actin filament polymerization)
GO:0030168 (platelet activation)
GO:0030334 (regulation of cell migration)
GO:0031295 (T cell costimulation)
GO:0031529 (ruffle organization)
GO:0032707 (negative regulation of interleukin-23 production)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0048261 (negative regulation of receptor-mediated endocytosis)
GO:0048870 (cell motility)
GO:0050690 (regulation of defense response to virus by virus)
GO:0051668 (localization within membrane)
GO:0060263 (regulation of respiratory burst)
Wikipedia RAC1

Target Cross References - Protein

canSAR P63000
Human Protein Atlas ENSG00000136238
IntAct P63000
PharmGKB PA34162
Reactome REACT_11044 (Signaling by Rho GTPases.)
REACT_11061 (Signalling by NGF.)
REACT_14797 (Signaling by GPCR.)
REACT_18266 (Axon guidance.)
REACT_23853 (Interactions of the immunoglobulin superfamily (IgSF) member proteins.)
REACT_604 (Hemostasis.)
REACT_6185 (HIV Infection.)
REACT_6900 (Signaling in Immune system.)
TIMBAL Rac1
UniProt O95501 P15154 P63000 Q3Y4D3 Q5JAA8 Q9BTB4

Target Cross References - Domain

InterPro IPR001806 (Ras_GTPase.)
IPR003578 (GTPase_Rho.)
IPR005225 (Small_GTP-bd_dom.)
IPR013753 (Ras.)
Pfam PF00071 (Ras)

Target Cross References - Structure

PDBe 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2VRW 2WKP 2WKQ 2WKR 3BJI
CREDO 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2VRW 2WKP 2WKQ 2WKR 3BJI
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