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Target Report Card

Target Name and Classification

Target ID CHEMBL6094
Preferred Name Ras-related C3 botulinum toxin substrate 1
Synonyms Cell migration-inducing gene 5 protein | RAC1 | Ras-like protein TC25 | Ras-related C3 botulinum toxin substrate 1 | TC25 | p21-Rac1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Ras-related C3 botulinum toxin substrate 1 SINGLE PROTEIN P63000

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301397 Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136238
Ensembl ENSG00000136238
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005802 (trans-Golgi network)
GO:0005829 (cytosol)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0030027 (lamellipodium)
GO:0030667 (secretory granule membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0032587 (ruffle membrane)
GO:0036464 (cytoplasmic ribonucleoprotein granule)
GO:0042470 (melanosome)
GO:0043197 (dendritic spine)
GO:0055038 (recycling endosome membrane)
GO:0070062 (extracellular exosome)
GO:0101003 (ficolin-1-rich granule membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0017137 (Rab GTPase binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0031996 (thioesterase binding)
GO:0042826 (histone deacetylase binding)
GO:0051022 (Rho GDP-dissociation inhibitor binding)
GO:0051117 (ATPase binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0002551 (mast cell chemotaxis)
GO:0006468 (protein phosphorylation)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0007015 (actin filament organization)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007596 (blood coagulation)
GO:0008283 (cell proliferation)
GO:0008361 (regulation of cell size)
GO:0009611 (response to wounding)
GO:0009653 (anatomical structure morphogenesis)
GO:0010310 (regulation of hydrogen peroxide metabolic process)
GO:0010591 (regulation of lamellipodium assembly)
GO:0010592 (positive regulation of lamellipodium assembly)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0016601 (Rac protein signal transduction)
GO:0030032 (lamellipodium assembly)
GO:0030036 (actin cytoskeleton organization)
GO:0030041 (actin filament polymerization)
GO:0030168 (platelet activation)
GO:0030334 (regulation of cell migration)
GO:0031116 (positive regulation of microtubule polymerization)
GO:0031295 (T cell costimulation)
GO:0031529 (ruffle organization)
GO:0032707 (negative regulation of interleukin-23 production)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0035556 (intracellular signal transduction)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043312 (neutrophil degranulation)
GO:0045453 (bone resorption)
GO:0045740 (positive regulation of DNA replication)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048012 (hepatocyte growth factor receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048261 (negative regulation of receptor-mediated endocytosis)
GO:0048870 (cell motility)
GO:0050690 (regulation of defense response to virus by virus)
GO:0051056 (regulation of small GTPase mediated signal transduction)
GO:0051492 (regulation of stress fiber assembly)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0051668 (localization within membrane)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
GO:0060263 (regulation of respiratory burst)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071526 (semaphorin-plexin signaling pathway)
GO:0090023 (positive regulation of neutrophil chemotaxis)
GO:0097178 (ruffle assembly)
GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading)
Wikipedia RAC1

Target Cross References - Protein

canSAR P63000
Human Protein Atlas ENSG00000136238
IntAct P63000
Open Targets ENSG00000136238
PharmGKB PA34162
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-164944 (Nef and signal transduction.)
R-HSA-193648 (NRAGE signals death through JNK.)
R-HSA-194840 (Rho GTPase cycle.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-399955 (SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.)
R-HSA-4086400 (PCP/CE pathway.)
R-HSA-416482 (G alpha (12/13) signalling events.)
R-HSA-416550 (Sema4D mediated inhibition of cell attachment and migration.)
R-HSA-418885 (DCC mediated attractive signaling.)
R-HSA-428540 (Activation of RAC1.)
R-HSA-428543 (Inactivation of CDC42 and RAC1.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5625740 (RHO GTPases activate PKNs.)
R-HSA-5625900 (RHO GTPases activate CIT.)
R-HSA-5625970 (RHO GTPases activate KTN1.)
R-HSA-5626467 (RHO GTPases activate IQGAPs.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
R-HSA-5663213 (RHO GTPases Activate WASPs and WAVEs.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-5668599 (RHO GTPases Activate NADPH Oxidases.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-8849471 (PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.)
R-HSA-8875555 (MET activates RAP1 and RAC1.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt O95501 P15154 P63000 Q3Y4D3 Q5JAA8 Q9BTB4

Target Cross References - Domain

InterPro IPR001806 (Small_GTPase.)
IPR003578 (Small_GTPase_Rho.)
IPR005225 (Small_GTP-bd_dom.)
IPR027417 (P-loop_NTPase.)
Pfam PF00071 (Ras)

Target Cross References - Structure

PDBe 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD More...
CREDO 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD More...