ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL6094
Target Type SINGLE PROTEIN
Preferred Name Ras-related C3 botulinum toxin substrate 1
Synonyms Cell migration-inducing gene 5 protein | RAC1 | Ras-like protein TC25 | Ras-related C3 botulinum toxin substrate 1 | TC25 | p21-Rac1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Ras-related C3 botulinum toxin substrate 1 SINGLE PROTEIN P63000

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301397 Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136238
Ensembl ENSG00000136238
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0001891 (phagocytic cup)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005802 (trans-Golgi network)
GO:0005829 (cytosol)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0019897 (extrinsic component of plasma membrane)
GO:0030027 (lamellipodium)
GO:0031012 (extracellular matrix)
GO:0031410 (cytoplasmic vesicle)
GO:0031901 (early endosome membrane)
GO:0032587 (ruffle membrane)
GO:0036464 (cytoplasmic ribonucleoprotein granule)
GO:0042470 (melanosome)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0017137 (Rab GTPase binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0030742 (GTP-dependent protein binding)
GO:0031996 (thioesterase binding)
GO:0042826 (histone deacetylase binding)
GO:0051022 (Rho GDP-dissociation inhibitor binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0002093 (auditory receptor cell morphogenesis)
GO:0002551 (mast cell chemotaxis)
GO:0003382 (epithelial cell morphogenesis)
GO:0006897 (endocytosis)
GO:0006911 (phagocytosis, engulfment)
GO:0006928 (movement of cell or subcellular component)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006972 (hyperosmotic response)
GO:0007010 (cytoskeleton organization)
GO:0007015 (actin filament organization)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007411 (axon guidance)
GO:0007596 (blood coagulation)
GO:0008283 (cell proliferation)
GO:0008361 (regulation of cell size)
GO:0009611 (response to wounding)
GO:0009653 (anatomical structure morphogenesis)
GO:0010310 (regulation of hydrogen peroxide metabolic process)
GO:0010592 (positive regulation of lamellipodium assembly)
GO:0010762 (regulation of fibroblast migration)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0014041 (regulation of neuron maturation)
GO:0016358 (dendrite development)
GO:0016477 (cell migration)
GO:0021799 (cerebral cortex radially oriented cell migration)
GO:0021831 (embryonic olfactory bulb interneuron precursor migration)
GO:0021894 (cerebral cortex GABAergic interneuron development)
GO:0022604 (regulation of cell morphogenesis)
GO:0030032 (lamellipodium assembly)
GO:0030036 (actin cytoskeleton organization)
GO:0030041 (actin filament polymerization)
GO:0030168 (platelet activation)
GO:0030334 (regulation of cell migration)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031295 (T cell costimulation)
GO:0031529 (ruffle organization)
GO:0032707 (negative regulation of interleukin-23 production)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0035556 (intracellular signal transduction)
GO:0035567 (non-canonical Wnt signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0043652 (engulfment of apoptotic cell)
GO:0045216 (cell-cell junction organization)
GO:0045453 (bone resorption)
GO:0045740 (positive regulation of DNA replication)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048261 (negative regulation of receptor-mediated endocytosis)
GO:0048532 (anatomical structure arrangement)
GO:0048812 (neuron projection morphogenesis)
GO:0048813 (dendrite morphogenesis)
GO:0048870 (cell motility)
GO:0048873 (homeostasis of number of cells within a tissue)
GO:0050690 (regulation of defense response to virus by virus)
GO:0051056 (regulation of small GTPase mediated signal transduction)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0051668 (localization within membrane)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0051932 (synaptic transmission, GABAergic)
GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
GO:0060263 (regulation of respiratory burst)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071526 (semaphorin-plexin signaling pathway)
GO:0071542 (dopaminergic neuron differentiation)
GO:0072659 (protein localization to plasma membrane)
GO:0090023 (positive regulation of neutrophil chemotaxis)
GO:0090103 (cochlea morphogenesis)
GO:0097178 (ruffle assembly)
GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading)
Wikipedia RAC1

Target Cross References - Protein

canSAR P63000
Human Protein Atlas ENSG00000136238
IntAct P63000
Open Targets ENSG00000136238
PharmGKB PA34162
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-164944 (Nef and signal transduction.)
R-HSA-193648 (NRAGE signals death through JNK.)
R-HSA-194840 (Rho GTPase cycle.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-399955 (SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.)
R-HSA-4086400 (PCP/CE pathway.)
R-HSA-416482 (G alpha (12/13) signalling events.)
R-HSA-416550 (Sema4D mediated inhibition of cell attachment and migration.)
R-HSA-416572 (Sema4D induced cell migration and growth-cone collapse.)
R-HSA-418885 (DCC mediated attractive signaling.)
R-HSA-428540 (Activation of Rac.)
R-HSA-428543 (Inactivation of Cdc42 and Rac.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5625740 (RHO GTPases activate PKNs.)
R-HSA-5625900 (RHO GTPases activate CIT.)
R-HSA-5625970 (RHO GTPases activate KTN1.)
R-HSA-5626467 (RHO GTPases activate IQGAPs.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
R-HSA-5663213 (RHO GTPases Activate WASPs and WAVEs.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-5668599 (RHO GTPases Activate NADPH Oxidases.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-8849471 (PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.)
R-HSA-8875555 (MET activates RAP1 and RAC1.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
TIMBAL Rac1
UniProt O95501 P15154 P63000 Q3Y4D3 Q5JAA8 Q9BTB4

Target Cross References - Domain

InterPro IPR001806 (Small_GTPase.)
IPR005225 (Small_GTP-bd_dom.)
IPR027417 (P-loop_NTPase.)
Pfam PF00071 (Ras)

Target Cross References - Structure

PDBe 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD More...
CREDO 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD More...
spacer
spacer