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Target Report Card

Target Name and Classification

Target ID CHEMBL6093
Target Type SINGLE PROTEIN
Preferred Name Calmodulin
Synonyms CALM | CALM3 | CAM | CAM1 | CAM3 | CAMB | CAMC | CAMIII | CaM | Calmodulin | andCALML2 | andCAM2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Calmodulin SINGLE PROTEIN P62158

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143933 ENSG00000160014 ENSG00000198668
Ensembl ENSG00000143933 ENSG00000160014 ENSG00000198668
GO Cellular Component GO:0000922 (spindle pole)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005876 (spindle microtubule)
GO:0005886 (plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0030017 (sarcomere)
GO:0030426 (growth cone)
GO:0031982 (vesicle)
GO:0034704 (calcium channel complex)
GO:0043005 (neuron projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008179 (adenylate cyclase binding)
GO:0008440 (inositol-1,4,5-trisphosphate 3-kinase activity)
GO:0015276 (ligand-gated ion channel activity)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0030234 (enzyme regulator activity)
GO:0030235 (nitric-oxide synthase regulator activity)
GO:0031432 (titin binding)
GO:0031800 (type 3 metabotropic glutamate receptor binding)
GO:0031996 (thioesterase binding)
GO:0031997 (N-terminal myristoylation domain binding)
GO:0043274 (phospholipase binding)
GO:0043539 (protein serine/threonine kinase activator activity)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0044325 (ion channel binding)
GO:0046872 (metal ion binding)
GO:0047485 (protein N-terminus binding)
GO:0048306 (calcium-dependent protein binding)
GO:0050998 (nitric-oxide synthase binding)
GO:0072542 (protein phosphatase activator activity)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000165 (MAPK cascade)
GO:0001975 (response to amphetamine)
GO:0002027 (regulation of heart rate)
GO:0002576 (platelet degranulation)
GO:0005513 (detection of calcium ion)
GO:0005980 (glycogen catabolic process)
GO:0006936 (muscle contraction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007223 (Wnt signaling pathway, calcium modulating pathway)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0010801 (negative regulation of peptidyl-threonine phosphorylation)
GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)
GO:0019722 (calcium-mediated signaling)
GO:0021762 (substantia nigra development)
GO:0022400 (regulation of rhodopsin mediated signaling pathway)
GO:0030801 (positive regulation of cyclic nucleotide metabolic process)
GO:0031954 (positive regulation of protein autophosphorylation)
GO:0032465 (regulation of cytokinesis)
GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
GO:0034220 (ion transmembrane transport)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043388 (positive regulation of DNA binding)
GO:0043547 (positive regulation of GTPase activity)
GO:0043647 (inositol phosphate metabolic process)
GO:0050999 (regulation of nitric-oxide synthase activity)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051343 (positive regulation of cyclic-nucleotide phosphodiesterase activity)
GO:0051412 (response to corticosterone)
GO:0051592 (response to calcium ion)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0060314 (regulation of ryanodine-sensitive calcium-release channel activity)
GO:0060315 (negative regulation of ryanodine-sensitive calcium-release channel activity)
GO:0060316 (positive regulation of ryanodine-sensitive calcium-release channel activity)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:1901841 (regulation of high voltage-gated calcium channel activity)
GO:1901844 (regulation of cell communication by electrical coupling involved in cardiac conduction)
Wikipedia Calmodulin_1

Target Cross References - Protein

canSAR P62158
CGD Ventricular tachycardia, catecholaminergic polymorphic, 4; Recurrent cardiac arrest, infantile
Human Protein Atlas ENSG00000143933 ENSG00000160014 ENSG00000198668
IntAct P62158
Open Targets ENSG00000143933 ENSG00000160014 ENSG00000198668
PharmGKB PA26042
Reactome R-HSA-111932 (CaMK IV-mediated phosphorylation of CREB.)
R-HSA-111933 (Calmodulin induced events.)
R-HSA-111957 (Cam-PDE 1 activation.)
R-HSA-111997 (CaM pathway.)
R-HSA-114608 (Platelet degranulation.)
R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-1474151 (Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.)
R-HSA-163615 (PKA activation.)
R-HSA-180024 (DARPP-32 events.)
R-HSA-1855204 (Synthesis of IP3 and IP4 in the cytosol.)
R-HSA-203615 (eNOS activation.)
R-HSA-2514859 (Inactivation, recovery and regulation of the phototransduction cascade.)
R-HSA-2672351 (Stimuli-sensing channels.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-418359 (Reduction of cytosolic Ca++ levels.)
R-HSA-425561 (Sodium/Calcium exchangers.)
R-HSA-442717 (CREB phosphorylation through the activation of CaMKK.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442745 (Activation of CaMK IV.)
R-HSA-442982 (Ras activation uopn Ca2+ infux through NMDA receptor.)
R-HSA-445355 (Smooth Muscle Contraction.)
R-HSA-451308 (Activation of Ca-permeable Kainate Receptor.)
R-HSA-5210891 (Uptake and function of anthrax toxins.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5607763 (CLEC7A (Dectin-1) induces NFAT activation.)
R-HSA-5626467 (RHO GTPases activate IQGAPs.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-70221 (Glycogen breakdown (glycogenolysis).)
R-HSA-8876725 (Protein methylation.)
R-HSA-936837 (Ion transport by P-type ATPases.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt P02593 P62158 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Target Cross References - Domain

InterPro IPR002048 (EF_hand_dom.)
IPR011992 (EF-hand-dom_pair.)
IPR018247 (EF_Hand_1_Ca_BS.)
Pfam PF13499 (EF-hand_7)

Target Cross References - Structure

PDBe 1CDL 1CLL 1CTR 1IWQ 1K90 1K93 1L7Z 1LVC 1PK0 1S26 1SK6 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ More...
CREDO 1CDL 1CLL 1CTR 1IWQ 1K90 1K93 1L7Z 1LVC 1PK0 1S26 1SK6 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ More...
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