ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL6093
Target Type SINGLE PROTEIN
Preferred Name Calmodulin
Synonyms CALM | CALM3 | CAM | CAM1 | CAM3 | CAMB | CAMC | CAMIII | CaM | Calmodulin | andCALML2 | andCAM2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Calmodulin SINGLE PROTEIN P62158

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143933 ENSG00000160014 ENSG00000198668
Ensembl ENSG00000143933 ENSG00000160014 ENSG00000198668
GO Cellular Component GO:0000922 (spindle pole)
GO:0005576 (extracellular region)
GO:0005654 (nucleoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005876 (spindle microtubule)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0005509 (calcium ion binding)
GO:0019904 (protein domain specific binding)
GO:0031432 (titin binding)
GO:0031996 (thioesterase binding)
GO:0031997 (N-terminal myristoylation domain binding)
GO:0043274 (phospholipase binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0005980 (glycogen catabolic process)
GO:0006006 (glucose metabolic process)
GO:0006936 (muscle contraction)
GO:0007186 (G-protein coupled receptor protein signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007268 (synaptic transmission)
GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0030168 (platelet activation)
GO:0032465 (regulation of cytokinesis)
GO:0046209 (nitric oxide metabolic process)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0050999 (regulation of nitric-oxide synthase activity)
GO:0051592 (response to calcium ion)
GO:0060315 (negative regulation of ryanodine-sensitive calcium-release channel activity)
GO:0060316 (positive regulation of ryanodine-sensitive calcium-release channel activity)
Wikipedia Calmodulin_1

Target Cross References - Protein

canSAR P62158
CGD Ventricular tachycardia, catecholaminergic polymorphic, 4; Recurrent cardiac arrest, infantile
Human Protein Atlas ENSG00000143933 ENSG00000160014 ENSG00000198668
IntAct P62158
PharmGKB PA26042
Reactome REACT_11061 (Signalling by NGF.)
REACT_12508 (Metabolism of nitric oxide.)
REACT_13685 (Synaptic Transmission.)
REACT_15295 (Opioid Signalling.)
REACT_17044 (Muscle contraction.)
REACT_474 (Metabolism of carbohydrates.)
REACT_604 (Hemostasis.)
UniProt P02593 P62158 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Target Cross References - Domain

InterPro IPR001125 (Recoverin.)
IPR002048 (EF_hand_Ca-bd.)
IPR011992 (EF-hand-like_dom.)
IPR018247 (EF_Hand_1_Ca_BS.)
IPR018248 (EF-hand.)
IPR018249 (EF_HAND_2.)
Pfam PF00036 (efhand)

Target Cross References - Structure

PDBe 1CDL 1CLL 1CTR 1IWQ 1K90 1K93 1L7Z 1LVC 1PK0 1S26 1SK6 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ More...
CREDO 1CDL 1CLL 1CTR 1IWQ 1K90 1K93 1L7Z 1LVC 1PK0 1S26 1SK6 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ More...
spacer
spacer