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Target Report Card

Target Name and Classification

Target ID CHEMBL6090
Preferred Name Actin-related protein 2
Synonyms ACTR2 | ARP2 | Actin-like protein 2 | Actin-related protein 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Actin-related protein 2 SINGLE PROTEIN P61160

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138071
Ensembl ENSG00000138071
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005885 (Arp2/3 protein complex)
GO:0005925 (focal adhesion)
GO:0005938 (cell cortex)
GO:0014069 (postsynaptic density)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0030027 (lamellipodium)
GO:0030478 (actin cap)
GO:0035578 (azurophil granule lumen)
GO:0042995 (cell projection)
GO:0061825 (podosome core)
GO:0070062 (extracellular exosome)
GO:0071437 (invadopodium)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003779 (actin binding)
GO:0005200 (structural constituent of cytoskeleton)
GO:0005524 (ATP binding)
GO:0008092 (cytoskeletal protein binding)
GO:0051015 (actin filament binding)
GO Biological Process GO:0007015 (actin filament organization)
GO:0007163 (establishment or maintenance of cell polarity)
GO:0008306 (associative learning)
GO:0008356 (asymmetric cell division)
GO:0016344 (meiotic chromosome movement towards spindle pole)
GO:0016482 (cytosolic transport)
GO:0030036 (actin cytoskeleton organization)
GO:0033206 (meiotic cytokinesis)
GO:0034314 (Arp2/3 complex-mediated actin nucleation)
GO:0035902 (response to immobilization stress)
GO:0035984 (cellular response to trichostatin A)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0043312 (neutrophil degranulation)
GO:0045471 (response to ethanol)
GO:0048013 (ephrin receptor signaling pathway)
GO:0051321 (meiotic cell cycle)
GO:0051653 (spindle localization)
GO:0060271 (cilium morphogenesis)
GO:0061003 (positive regulation of dendritic spine morphogenesis)
GO:0061024 (membrane organization)
GO:0071346 (cellular response to interferon-gamma)
Wikipedia ACTR2

Target Cross References - Protein

canSAR P61160
Human Protein Atlas ENSG00000138071
IntAct P61160
Open Targets ENSG00000138071
PharmGKB PA24488
Reactome R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-5663213 (RHO GTPases Activate WASPs and WAVEs.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt B2RCP5 D6W5F4 E9PF41 O15142 P61160 Q96C82

Target Cross References - Domain

InterPro IPR004000 (Actin.)
IPR020902 (Actin/actin-like_CS.)
IPR027306 (Arp2.)
Pfam PF00022 (Actin)