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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6089
Target Type SINGLE PROTEIN
Preferred Name Ubiquitin-conjugating enzyme E2 N
Synonyms BLU | Bendless-like ubiquitin-conjugating enzyme | UBE2N | Ubc13 | UbcH13 | Ubiquitin carrier protein N | Ubiquitin-conjugating enzyme E2 N | Ubiquitin-protein ligase N
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Ubiquitin-conjugating enzyme E2 N SINGLE PROTEIN P61088

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177889
Ensembl ENSG00000177889
GO Cellular Component GO:0000151 (ubiquitin ligase complex)
GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO:0031372 (UBC13-MMS2 complex)
GO:0035370 (UBC13-UEV1A complex)
GO Molecular Function GO:0004842 (ubiquitin-protein ligase activity)
GO:0005524 (ATP binding)
GO:0043130 (ubiquitin binding)
GO Biological Process GO:0000724 (double-strand break repair via homologous recombination)
GO:0000729 (DNA double-strand break processing)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006301 (postreplication repair)
GO:0006508 (proteolysis)
GO:0008063 (Toll signaling pathway)
GO:0016574 (histone ubiquitination)
GO:0031058 (positive regulation of histone modification)
GO:0033182 (regulation of histone ubiquitination)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0045087 (innate immune response)
GO:0045739 (positive regulation of DNA repair)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051443 (positive regulation of ubiquitin-protein ligase activity)
GO:0070534 (protein K63-linked ubiquitination)
Wikipedia UBE2N

Target Cross References - Protein

canSAR P61088
Human Protein Atlas ENSG00000177889
IntAct P61088
PharmGKB PA37141
Reactome REACT_6900 (Signaling in Immune system.)
UniProt P61088 Q16781 Q53Y81

Target Cross References - Domain

InterPro IPR000608 (UBQ-conjugat_E2.)
IPR016135 (UBQ-conjugating_enzyme/RWD.)
IPR023313 (UBQ-conjugating_AS.)
Pfam PF00179 (UQ_con)

Target Cross References - Structure

PDBe 1J7D 2C2V 3HCT 3HCU
CREDO 1J7D 2C2V 3HCT 3HCU
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