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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL6089
Target Type SINGLE PROTEIN
Preferred Name Ubiquitin-conjugating enzyme E2 N
Synonyms BLU | Bendless-like ubiquitin-conjugating enzyme | E2 ubiquitin-conjugating enzyme N | UBE2N | Ubc13 | UbcH13 | Ubiquitin carrier protein N | Ubiquitin-conjugating enzyme E2 N | Ubiquitin-protein ligase N
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Ubiquitin-conjugating enzyme E2 N SINGLE PROTEIN P61088

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177889
Ensembl ENSG00000177889
GO Cellular Component GO:0000151 (ubiquitin ligase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0031372 (UBC13-MMS2 complex)
GO:0035370 (UBC13-UEV1A complex)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004842 (ubiquitin-protein transferase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016740 (transferase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0043130 (ubiquitin binding)
GO:0044822 (poly(A) RNA binding)
GO:0061630 (ubiquitin protein ligase activity)
GO:0061631 (ubiquitin conjugating enzyme activity)
GO Biological Process GO:0000724 (double-strand break repair via homologous recombination)
GO:0000729 (DNA double-strand break processing)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006281 (DNA repair)
GO:0006282 (regulation of DNA repair)
GO:0006301 (postreplication repair)
GO:0006303 (double-strand break repair via nonhomologous end joining)
GO:0006464 (cellular protein modification process)
GO:0006508 (proteolysis)
GO:0006511 (ubiquitin-dependent protein catabolic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0016567 (protein ubiquitination)
GO:0016574 (histone ubiquitination)
GO:0031058 (positive regulation of histone modification)
GO:0033182 (regulation of histone ubiquitination)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045739 (positive regulation of DNA repair)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051443 (positive regulation of ubiquitin-protein transferase activity)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0070534 (protein K63-linked ubiquitination)
GO:0070911 (global genome nucleotide-excision repair)
Wikipedia UBE2N

Target Cross References - Protein

canSAR P61088
Human Protein Atlas ENSG00000177889
IntAct P61088
Open Targets ENSG00000177889
PharmGKB PA37141
Reactome R-HSA-1169408 (ISG15 antiviral mechanism.)
R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-446652 (Interleukin-1 signaling.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-HSA-5693571 (Nonhomologous End-Joining (NHEJ).)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-5696395 (Formation of Incision Complex in GG-NER.)
R-HSA-69473 (G2/M DNA damage checkpoint.)
R-HSA-8866654 (E3 ubiquitin ligases ubiquitinate target proteins.)
R-HSA-937039 (IRAK1 recruits IKK complex.)
R-HSA-937041 (IKK complex recruitment mediated by RIP1.)
R-HSA-975110 (TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.)
R-HSA-975144 (IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.)
R-HSA-983168 (Antigen processing: Ubiquitination & Proteasome degradation.)
UniProt P61088 Q16781 Q53Y81

Target Cross References - Domain

InterPro IPR000608 (UBQ-conjugat_E2.)
IPR016135 (UBQ-conjugating_enzyme/RWD.)
IPR023313 (UBQ-conjugating_AS.)
Pfam PF00179 (UQ_con)

Target Cross References - Structure

PDBe 1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA
CREDO 1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA
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