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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6055
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase WNK3
Synonyms KIAA1566 | PRKWNK3 | Protein kinase lysine-deficient 3 | Protein kinase with no lysine 3 | Serine/threonine-protein kinase WNK3 | WNK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase wnk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase WNK3 SINGLE PROTEIN Q9BYP7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196632
Ensembl ENSG00000196632
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005912 (adherens junction)
GO:0005923 (bicellular tight junction)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019869 (chloride channel inhibitor activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0010765 (positive regulation of sodium ion transport)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0016310 (phosphorylation)
GO:0032414 (positive regulation of ion transmembrane transporter activity)
GO:0035556 (intracellular signal transduction)
GO:0043066 (negative regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0051928 (positive regulation of calcium ion transport)
GO:0090004 (positive regulation of establishment of protein localization to plasma membrane)
GO:0090188 (negative regulation of pancreatic juice secretion)
GO:2000021 (regulation of ion homeostasis)
GO:2000651 (positive regulation of sodium ion transmembrane transporter activity)
GO:2000682 (positive regulation of rubidium ion transport)
GO:2000688 (positive regulation of rubidium ion transmembrane transporter activity)
Wikipedia WNK3

Target Cross References - Protein

Human Protein Atlas ENSG00000196632
IntAct Q9BYP7
Guide to Pharmacology 2282
Open Targets ENSG00000196632
PharmGKB PA33784
Pharos Q9BYP7 (Tbio)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
UniProt B1AKG2 Q5JRC1 Q6JP76 Q8TCX6 Q9BYP7 Q9HCK6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR024678 (Kinase_OSR1/WNK_CCT.)
Pfam PF00069 (Pkinase)
PF12202 (OSR1_C)
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