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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6032
Target Type SINGLE PROTEIN
Preferred Name Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
Synonyms BAT8 | C6orf30 | EHMT2 | Euchromatic histone-lysine N-methyltransferase 2 | G9A | H3-K9-HMTase 3 | HLA-B-associated transcript 8 | Histone H3-K9 methyltransferase 3 | Histone-lysine N-methyltransferase EHMT2 | KMT1C | Lysine N-methyltransferase 1C | NG36 | Protein G9a
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > protein methyltransferase

Target Components

Component Description Relationship Accession
Histone-lysine N-methyltransferase EHMT2 SINGLE PROTEIN Q96KQ7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204371 ENSG00000206376 ENSG00000227333 ENSG00000232045 ENSG00000236759 ENSG00000238134
Ensembl ENSG00000204371 ENSG00000206376 ENSG00000227333 ENSG00000232045 ENSG00000236759 ENSG00000238134
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO Molecular Function GO:0002039 (p53 binding)
GO:0005515 (protein binding)
GO:0008168 (methyltransferase activity)
GO:0008270 (zinc ion binding)
GO:0016279 (protein-lysine N-methyltransferase activity)
GO:0016740 (transferase activity)
GO:0018024 (histone-lysine N-methyltransferase activity)
GO:0046872 (metal ion binding)
GO:0046974 (histone methyltransferase activity (H3-K9 specific))
GO:0046976 (histone methyltransferase activity (H3-K27 specific))
GO:0070742 (C2H2 zinc finger domain binding)
GO:1990841 (promoter-specific chromatin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006275 (regulation of DNA replication)
GO:0006306 (DNA methylation)
GO:0009267 (cellular response to starvation)
GO:0016568 (chromatin modification)
GO:0016571 (histone methylation)
GO:0018027 (peptidyl-lysine dimethylation)
GO:0032259 (methylation)
GO:0034968 (histone lysine methylation)
GO:0051567 (histone H3-K9 methylation)
GO:0070734 (histone H3-K27 methylation)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia EHMT2

Target Cross References - Protein

canSAR Q96KQ7
Human Protein Atlas ENSG00000204371 ENSG00000206376 ENSG00000227333 ENSG00000232045 ENSG00000236759 ENSG00000238134
IntAct Q96KQ7
Guide to Pharmacology 2652
Open Targets ENSG00000204371 ENSG00000206376 ENSG00000227333 ENSG00000232045 ENSG00000236759 ENSG00000238134
PharmGKB PA25267
Reactome R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-3214841 (PKMTs methylate histone lysines.)
R-HSA-427389 (ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.)
R-HSA-6804760 (Regulation of TP53 Activity through Methylation.)
R-HSA-73762 (RNA Polymerase I Transcription Initiation.)
UniProt B0UZY2 Q14349 Q5JP83 Q5JQ92 Q5JQA1 Q5JQG3 Q6PK06 Q96KQ7 Q96MH5 Q96QD0 Q9UQL8 Q9Y331

Target Cross References - Domain

InterPro IPR001214 (SET_dom.)
IPR002110 (Ankyrin_rpt.)
IPR007728 (Pre-SET_dom.)
IPR020683 (Ankyrin_rpt-contain_dom.)
Pfam PF00856 (SET)
PF05033 (Pre-SET)
PF12796 (Ank_2)

Target Cross References - Structure

PDBe 2O8J 3DM1 3K5K 3RJW 4NVQ
CREDO 2O8J 3DM1 3K5K 3RJW 4NVQ
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