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Target Report Card

Target Name and Classification

Target ID CHEMBL6029
Preferred Name Eukaryotic translation initiation factor 2-alpha kinase 1
Synonyms EIF2AK1 | Eukaryotic translation initiation factor 2-alpha kinase 1 | HCR | HRI | Heme-controlled repressor | Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase | Heme-regulated inhibitor | Hemin-sensitive initiation factor 2-alpha kinase | KIAA1369
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase pek family > other protein kinase hri

Target Components

Component Description Relationship Accession
Eukaryotic translation initiation factor 2-alpha kinase 1 SINGLE PROTEIN Q9BQI3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000086232
Ensembl ENSG00000086232
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004694 (eukaryotic translation initiation factor 2alpha kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0020037 (heme binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0002526 (acute inflammatory response)
GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006909 (phagocytosis)
GO:0006950 (response to stress)
GO:0008285 (negative regulation of cell proliferation)
GO:0009605 (response to external stimulus)
GO:0010998 (regulation of translational initiation by eIF2 alpha phosphorylation)
GO:0010999 (regulation of eIF2 alpha phosphorylation by heme)
GO:0016310 (phosphorylation)
GO:0017148 (negative regulation of translation)
GO:0030225 (macrophage differentiation)
GO:0045993 (negative regulation of translational initiation by iron)
GO:0046501 (protoporphyrinogen IX metabolic process)
GO:0046777 (protein autophosphorylation)
GO:0046984 (regulation of hemoglobin biosynthetic process)
GO:0046986 (negative regulation of hemoglobin biosynthetic process)
GO:0055072 (iron ion homeostasis)
Wikipedia EIF2AK1

Target Cross References - Protein

Human Protein Atlas ENSG00000086232
IntAct Q9BQI3
Guide to Pharmacology 2015
Open Targets ENSG00000086232
PharmGKB PA134919097
Pharos Q9BQI3 (Tchem)
UniProt A8K2R2 Q549K6 Q8NBW3 Q9BQI3 Q9HC02 Q9NYE0 Q9P0V6 Q9P1J5 Q9P2H8 Q9UHG4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)