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Target Report Card

Target Name and Classification

Target ID CHEMBL6029
Preferred Name Eukaryotic translation initiation factor 2-alpha kinase 1
Synonyms EIF2AK1 | Eukaryotic translation initiation factor 2-alpha kinase 1 | HCR | HRI | Heme-controlled repressor | Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase | Heme-regulated inhibitor | Hemin-sensitive initiation factor 2-alpha kinase | KIAA1369
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase pek family > other protein kinase hri

Target Components

Component Description Relationship Accession
Eukaryotic translation initiation factor 2-alpha kinase 1 SINGLE PROTEIN Q9BQI3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000086232
Ensembl ENSG00000086232
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0004694 (eukaryotic translation initiation factor 2alpha kinase activity)
GO:0005524 (ATP binding)
GO:0020037 (heme binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006950 (response to stress)
GO:0009605 (response to external stimulus)
GO:0045993 (negative regulation of translational initiation by iron)
GO:0046777 (protein autophosphorylation)
GO:0046986 (negative regulation of hemoglobin biosynthetic process)
Wikipedia EIF2AK1

Target Cross References - Protein

Human Protein Atlas ENSG00000086232
IntAct Q9BQI3
Guide to Pharmacology 2015 (eukaryotic translation initiation factor 2-alpha kinase 1)
PharmGKB PA134919097
UniProt A8K2R2 Q549K6 Q8NBW3 Q9BQI3 Q9HC02 Q9NYE0 Q9P0V6 Q9P1J5 Q9P2H8 Q9UHG4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015516 (Haem-reg_EIF2A_Kinase.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)