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Target Report Card

Target Name and Classification

Target ID CHEMBL6028
Preferred Name Segment polarity protein dishevelled homolog DVL-3
Synonyms DSH homolog 3 | DVL3 | Dishevelled-3 | KIAA0208 | Segment polarity protein dishevelled homolog DVL-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Segment polarity protein dishevelled homolog DVL-3 SINGLE PROTEIN Q92997

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000161202
Ensembl ENSG00000161202
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0002020 (protease binding)
GO:0004871 (signal transducer activity)
GO:0005102 (receptor binding)
GO:0005109 (frizzled binding)
GO:0008013 (beta-catenin binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0003148 (outflow tract septum morphogenesis)
GO:0016055 (Wnt signaling pathway)
GO:0035556 (intracellular signal transduction)
GO:0035567 (non-canonical Wnt signaling pathway)
GO:0038031 (non-canonical Wnt signaling pathway via JNK cascade)
GO:0042493 (response to drug)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0045893 (positive regulation of transcription, DNA-dependent)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0060070 (canonical Wnt receptor signaling pathway)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090103 (cochlea morphogenesis)
GO:0090179 (planar cell polarity pathway involved in neural tube closure)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1903827 (regulation of cellular protein localization)
Wikipedia DVL3

Target Cross References - Protein

canSAR Q92997
Human Protein Atlas ENSG00000161202
IntAct Q92997
PharmGKB PA27543
UniProt D3DNT0 O14642 Q13531 Q8N5E9 Q92607 Q92997

Target Cross References - Domain

InterPro IPR000591 (DEP_dom.)
IPR001158 (DIX.)
IPR001478 (PDZ.)
IPR003351 (Dishevelled_protein.)
IPR003351 (Dishevelled_protein_dom.)
IPR008339 (Dishevelled.)
IPR008339 (Dishevelled_fam.)
IPR008342 (DVL3.)
IPR008342 (Dishevelled_3.)
IPR011991 (WHTH_DNA-bd_dom.)
IPR011991 (WHTH_trsnscrt_rep_DNA-bd.)
IPR015506 (Dsh.)
IPR015506 (Dsh/Dvl-rel.)
IPR024580 (Dishevelled_C-dom.)
IPR029071 (Ubiquitin-rel_dom.)
Pfam PF00595 (PDZ)
PF00610 (DEP)
PF00778 (DIX)
PF02377 (Dishevelled)
PF12316 (Dsh_C)