ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL6028
Target Type SINGLE PROTEIN
Preferred Name Segment polarity protein dishevelled homolog DVL-3
Synonyms DSH homolog 3 | DVL3 | Dishevelled-3 | KIAA0208 | Segment polarity protein dishevelled homolog DVL-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Segment polarity protein dishevelled homolog DVL-3 SINGLE PROTEIN Q92997

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000161202
Ensembl ENSG00000161202
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0002020 (protease binding)
GO:0004871 (signal transducer activity)
GO:0005102 (receptor binding)
GO:0005109 (frizzled binding)
GO:0008013 (beta-catenin binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0003148 (outflow tract septum morphogenesis)
GO:0016055 (Wnt signaling pathway)
GO:0035556 (intracellular signal transduction)
GO:0035567 (non-canonical Wnt signaling pathway)
GO:0038031 (non-canonical Wnt signaling pathway via JNK cascade)
GO:0042493 (response to drug)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0045893 (positive regulation of transcription, DNA-dependent)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0060070 (canonical Wnt receptor signaling pathway)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090103 (cochlea morphogenesis)
GO:0090179 (planar cell polarity pathway involved in neural tube closure)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1903827 (regulation of cellular protein localization)
Wikipedia DVL3

Target Cross References - Protein

canSAR Q92997
Human Protein Atlas ENSG00000161202
IntAct Q92997
PharmGKB PA27543
UniProt D3DNT0 O14642 Q13531 Q8N5E9 Q92607 Q92997

Target Cross References - Domain

InterPro IPR000591 (DEP_dom.)
IPR001158 (DIX.)
IPR001478 (PDZ.)
IPR001478 (PDZ/DHR/GLGF.)
IPR003351 (Dishevelled_protein.)
IPR003351 (Dishevelled_protein_dom.)
IPR008339 (Dishevelled.)
IPR008339 (Dishevelled_fam.)
IPR008342 (DVL3.)
IPR008342 (Dishevelled_3.)
IPR011991 (WHTH_DNA-bd_dom.)
IPR011991 (WHTH_trsnscrt_rep_DNA-bd.)
IPR015506 (Dsh.)
IPR015506 (Dsh/Dvl-rel.)
IPR024580 (Dishevelled_C-dom.)
IPR029071 (Ubiquitin-rel_dom.)
Pfam PF00595 (PDZ)
PF00610 (DEP)
PF00778 (DIX)
PF02377 (Dishevelled)
PF12316 (Dsh_C)
spacer
spacer