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Target Report Card

Target Name and Classification

Target ID CHEMBL6020
Preferred Name Bile salt export pump
Synonyms ABCB11 | ATP-binding cassette sub-family B member 11 | BSEP | Bile salt export pump
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcb subfamily

Target Components

Component Description Relationship Accession
Bile salt export pump SINGLE PROTEIN O95342

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073734
Ensembl ENSG00000073734
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045177 (apical part of cell)
GO:0046581 (intercellular canaliculus)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005215 (transporter activity)
GO:0005524 (ATP binding)
GO:0008554 (sodium-exporting ATPase activity, phosphorylative mechanism)
GO:0015126 (canalicular bile acid transmembrane transporter activity)
GO:0015432 (bile acid-exporting ATPase activity)
GO:0016887 (ATPase activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO Biological Process GO:0006699 (bile acid biosynthetic process)
GO:0006810 (transport)
GO:0015721 (bile acid and bile salt transport)
GO:0015722 (canalicular bile acid transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0055085 (transmembrane transport)
Wikipedia ABCB11

Target Cross References - Protein

canSAR O95342
CGD Cholestasis, progressive familial intrahepatic 2
Human Protein Atlas ENSG00000073734
IntAct O95342
Guide to Pharmacology 778
Open Targets ENSG00000073734
PharmGKB PA374
Reactome R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
UniProt O95342 Q53TL2 Q9UNB2

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
IPR030278 (BSEP.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)