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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6007
Target Type SINGLE PROTEIN
Preferred Name Transient receptor potential cation channel subfamily A member 1
Synonyms ANKTM1 | Ankyrin-like with transmembrane domains protein 1 | TRPA1 | Transformation-sensitive protein p120 | Transient receptor potential cation channel subfamily A member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > transient receptor potential channel

Target Components

Component Description Relationship Accession
Transient receptor potential cation channel subfamily A member 1 SINGLE PROTEIN O75762

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL256087 MENTHOL Transient receptor potential cation channel subfamily A member 1 opener 4 PubMed
CHEMBL3707318 GRC-17536 Transient receptor potential cation channel subfamily A member 1 antagonist 2 Other PubMed
CHEMBL3707378 CB-189625 Transient receptor potential cation channel subfamily A member 1 antagonist 0 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104321
Ensembl ENSG00000104321
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0032421 (stereocilium bundle)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005262 (calcium channel activity)
GO:0015267 (channel activity)
GO:0015278 (calcium-release channel activity)
GO:0097604 (temperature-gated cation channel activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007166 (cell surface receptor signaling pathway)
GO:0009409 (response to cold)
GO:0010033 (response to organic substance)
GO:0014070 (response to organic cyclic compound)
GO:0019233 (sensory perception of pain)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0048265 (response to pain)
GO:0050896 (response to stimulus)
GO:0050955 (thermoception)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0050968 (detection of chemical stimulus involved in sensory perception of pain)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051289 (protein homotetramerization)
GO:0055085 (transmembrane transport)
GO:0070588 (calcium ion transmembrane transport)
Wikipedia Transient_receptor_potential_cation_channel,_member_A1

Target Cross References - Protein

CGD Episodic pain syndrome, familial
Human Protein Atlas ENSG00000104321
IntAct O75762
Guide to Pharmacology 485
Open Targets ENSG00000104321
Pharos O75762 (Tclin)
Reactome R-HSA-3295583 (TRP channels.)
UniProt A6NIN6 O75762

Target Cross References - Domain

InterPro IPR002110 (Ankyrin_rpt.)
IPR005821 (Ion_trans_dom.)
IPR020683 (Ankyrin_rpt-contain_dom.)
Pfam PF00520 (Ion_trans)
PF12796 (Ank_2)
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