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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5999
Target Type SINGLE PROTEIN
Preferred Name 3-keto-steroid reductase
Synonyms 17-beta-HSD 7 | 17-beta-hydroxysteroid dehydrogenase 7 | 3-keto-steroid reductase | Estradiol 17-beta-dehydrogenase 7 | HSD17B7 | SDR37C1 | Short chain dehydrogenase/reductase family 37C member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
3-keto-steroid reductase SINGLE PROTEIN P56937

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132196
Ensembl ENSG00000132196
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000253 (3-keto sterol reductase activity)
GO:0004303 (estradiol 17-beta-dehydrogenase activity)
GO:0016491 (oxidoreductase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006703 (estrogen biosynthetic process)
GO:0055114 (oxidation-reduction process)
Wikipedia HSD17B7

Target Cross References - Protein

canSAR P56937
Human Protein Atlas ENSG00000132196
IntAct P56937
Open Targets ENSG00000132196
PharmGKB PA29483
Reactome R-HSA-191273 (Cholesterol biosynthesis.)
UniProt P56937 Q5T246 Q7Z4V9 Q8WWS2 Q9UF00

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR016040 (NAD(P)-bd_dom.)
Pfam PF00106 (adh_short)
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