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Target Report Card

Target Name and Classification

Target ID CHEMBL5993
Preferred Name 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Synonyms 25-OHD-1 alpha-hydroxylase | 25-hydroxyvitamin D(3) 1-alpha-hydroxylase | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CYP1ALPHA | CYP27B | CYP27B1 | Calcidiol 1-monooxygenase | Cytochrome P450 subfamily XXVIIB polypeptide 1 | Cytochrome P450C1 alpha | Cytochrome P450VD1-alpha | Cytochrome p450 27B1 | VD3 1A hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial SINGLE PROTEIN O15528

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111012
Ensembl ENSG00000111012
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004498 (calcidiol 1-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006766 (vitamin metabolic process)
GO:0006816 (calcium ion transport)
GO:0008285 (negative regulation of cell proliferation)
GO:0010956 (negative regulation of calcidiol 1-monooxygenase activity)
GO:0010980 (positive regulation of vitamin D 24-hydroxylase activity)
GO:0030282 (bone mineralization)
GO:0030308 (negative regulation of cell growth)
GO:0030500 (regulation of bone mineralization)
GO:0032496 (response to lipopolysaccharide)
GO:0033280 (response to vitamin D)
GO:0034341 (response to interferon-gamma)
GO:0036378 (calcitriol biosynthetic process from calciol)
GO:0042359 (vitamin D metabolic process)
GO:0042369 (vitamin D catabolic process)
GO:0043627 (response to estrogen)
GO:0045618 (positive regulation of keratinocyte differentiation)
GO:0046697 (decidualization)
GO:0055074 (calcium ion homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0070314 (G1 to G0 transition)
GO:0070564 (positive regulation of vitamin D receptor signaling pathway)
Wikipedia 25-Hydroxyvitamin_D3_1-alpha-hydroxylase

Target Cross References - Protein

canSAR O15528
CGD Vitamin D-dependent rickets, type 1A
Human Protein Atlas ENSG00000111012
Guide to Pharmacology 1370
Open Targets ENSG00000111012
PharmGKB PA27099
Reactome R-HSA-196791 (Vitamin D (calciferol) metabolism.)
R-HSA-211916 (Vitamins.)
R-HSA-5579014 (Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A).)
UniProt B2RC61 O15528 Q548T3

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)