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Target Report Card

Target Name and Classification

Target ID CHEMBL5992
Target Type SINGLE PROTEIN
Preferred Name Sterol 26-hydroxylase, mitochondrial
Synonyms 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase | CYP27 | CYP27A1 | Cytochrome P-450C27/25 | Cytochrome P450 27 | Sterol 26-hydroxylase, mitochondrial | Sterol 27-hydroxylase | Vitamin D(3) 25-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Sterol 26-hydroxylase, mitochondrial SINGLE PROTEIN Q02318

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135929
Ensembl ENSG00000135929
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006699 (bile acid biosynthetic process)
GO:0016125 (sterol metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP27A1

Target Cross References - Protein

canSAR Q02318
CGD Cerebrotendinous xanthomatosis
Human Protein Atlas ENSG00000135929
IntAct Q02318
Guide to Pharmacology 1369
Open Targets ENSG00000135929
PharmGKB PA135
Reactome R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-5578996 (Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX).)
UniProt A8K303 Q02318 Q6LDB4 Q86YQ6

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)
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