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Target Report Card

Target Name and Classification

Target ID CHEMBL5990
Preferred Name Breast cancer type 1 susceptibility protein
Synonyms BRCA1 | Breast cancer type 1 susceptibility protein | RING finger protein 53 | RNF53
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Breast cancer type 1 susceptibility protein SINGLE PROTEIN P38398

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000012048
Ensembl ENSG00000012048
GO Cellular Component GO:0001726 (ruffle)
GO:0005654 (nucleoplasm)
GO:0005886 (plasma membrane)
GO:0008274 (gamma-tubulin ring complex)
GO:0030529 (ribonucleoprotein complex)
GO:0031436 (BRCA1-BARD1 complex)
GO:0070531 (BRCA1-A complex)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0003723 (RNA binding)
GO:0004842 (ubiquitin-protein ligase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0010843 (promoter binding)
GO:0015631 (tubulin binding)
GO:0016563 (transcription activator activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042802 (identical protein binding)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0000724 (double-strand break repair via homologous recombination)
GO:0006301 (postreplication repair)
GO:0006359 (regulation of transcription from RNA polymerase III promoter)
GO:0006633 (fatty acid biosynthetic process)
GO:0006915 (apoptosis)
GO:0006978 (DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)
GO:0007059 (chromosome segregation)
GO:0008630 (DNA damage response, signal transduction resulting in induction of apoptosis)
GO:0010212 (response to ionizing radiation)
GO:0030521 (androgen receptor signaling pathway)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0031572 (G2/M transition DNA damage checkpoint)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035066 (positive regulation of histone acetylation)
GO:0042127 (regulation of cell proliferation)
GO:0043627 (response to estrogen stimulus)
GO:0045717 (negative regulation of fatty acid biosynthetic process)
GO:0045739 (positive regulation of DNA repair)
GO:0045892 (negative regulation of transcription, DNA-dependent)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046600 (negative regulation of centriole replication)
GO:0051571 (positive regulation of histone H3-K4 methylation)
GO:0051573 (negative regulation of histone H3-K9 methylation)
GO:0051865 (protein autoubiquitination)
GO:0070512 (positive regulation of histone H4-K20 methylation)
GO:0071158 (positive regulation of cell cycle arrest)
GO:0071681 (cellular response to indole-3-methanol)
GO:0085020 (protein K6-linked ubiquitination)
GO:2000145 (regulation of cell motility)
Wikipedia BRCA1

Target Cross References - Protein

canSAR P38398
CGD Breast-ovarian cancer, familial, susceptibility to, 1; Pancreatic cancer, susceptibility to
Human Protein Atlas ENSG00000012048
IntAct P38398
PharmGKB PA25411
Reactome REACT_216 (DNA Repair.)
REACT_27271 (Meiotic Recombination.)
UniProt O15129 P38398 Q3LRJ0 Q7KYU9

Target Cross References - Domain

InterPro IPR001357 (BRCT.)
IPR001841 (Znf_RING.)
IPR002378 (Brst_cancerI.)
IPR006957 (EIN3.)
IPR011364 (BRCA1.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR017907 (Znf_RING_CS.)
IPR018957 (Znf_C3HC4_RING-type.)
Pfam PF00097 (zf-C3HC4)
PF00533 (BRCT)
PF04873 (EIN3)

Target Cross References - Structure

PDBe 1JNX 1N5O 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE
CREDO 1JNX 1N5O 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE