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Target Report Card

Target Name and Classification

Target ID CHEMBL5989
Target Type SINGLE PROTEIN
Preferred Name Baculoviral IAP repeat-containing protein 5
Synonyms API4 | Apoptosis inhibitor 4 | Apoptosis inhibitor survivin | BIRC5 | Baculoviral IAP repeat-containing protein 5 | IAP4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Baculoviral IAP repeat-containing protein 5 SINGLE PROTEIN O15392

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089685
Ensembl ENSG00000089685
GO Cellular Component GO:0000228 (nuclear chromosome)
GO:0000775 (chromosome, centromeric region)
GO:0000776 (kinetochore)
GO:0000777 (condensed chromosome kinetochore)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005814 (centriole)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005876 (spindle microtubule)
GO:0005881 (cytoplasmic microtubule)
GO:0030496 (midbody)
GO:0031021 (interphase microtubule organizing center)
GO:0032133 (chromosome passenger complex)
GO Molecular Function GO:0004842 (ubiquitin-protein transferase activity)
GO:0004869 (cysteine-type endopeptidase inhibitor activity)
GO:0005515 (protein binding)
GO:0008017 (microtubule binding)
GO:0008270 (zinc ion binding)
GO:0008536 (Ran GTPase binding)
GO:0015631 (tubulin binding)
GO:0019899 (enzyme binding)
GO:0030414 (peptidase inhibitor activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0048037 (cofactor binding)
GO:0050897 (cobalt ion binding)
GO:0051087 (chaperone binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000910 (cytokinesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0007062 (sister chromatid cohesion)
GO:0007067 (mitotic nuclear division)
GO:0008284 (positive regulation of cell proliferation)
GO:0009966 (regulation of signal transduction)
GO:0010466 (negative regulation of peptidase activity)
GO:0016567 (protein ubiquitination)
GO:0016925 (protein sumoylation)
GO:0031503 (protein complex localization)
GO:0031536 (positive regulation of exit from mitosis)
GO:0031577 (spindle checkpoint)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0051301 (cell division)
GO:0051303 (establishment of chromosome localization)
GO:0090307 (mitotic spindle assembly)
GO:1990001 (inhibition of cysteine-type endopeptidase activity involved in apoptotic process)
Wikipedia Survivin

Target Cross References - Protein

canSAR O15392
Human Protein Atlas ENSG00000089685
IntAct O15392
Guide to Pharmacology 2795
Open Targets ENSG00000089685
PharmGKB PA25362
Reactome R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-4615885 (SUMOylation of DNA replication proteins.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6803205 (TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.)
R-HSA-68877 (Mitotic Prometaphase.)
UniProt A2SUH6 B2R4R1 O15392 Q2I3N8 Q4VGX0 Q53F61 Q5MGC6 Q6FHL2 Q75SP2 Q9P2W8

Target Cross References - Domain

InterPro IPR001370 (BIR_rpt.)
Pfam PF00653 (BIR)

Target Cross References - Structure

PDBe 1E31 1F3H 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
CREDO 1E31 1F3H 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
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