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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5987
Target Type SINGLE PROTEIN
Preferred Name ADP-ribosylation factor 6
Synonyms ADP-ribosylation factor 6 | ARF6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
ADP-ribosylation factor 6 SINGLE PROTEIN P62330

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165527
Ensembl ENSG00000165527
GO Cellular Component GO:0001726 (ruffle)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0005938 (cell cortex)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0030139 (endocytic vesicle)
GO:0030496 (midbody)
GO:0031527 (filopodium membrane)
GO:0032154 (cleavage furrow)
GO:0042995 (cell projection)
GO:0043209 (myelin sheath)
GO:0055037 (recycling endosome)
GO:0055038 (recycling endosome membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0031996 (thioesterase binding)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0001889 (liver development)
GO:0006810 (transport)
GO:0006928 (movement of cell or subcellular component)
GO:0007049 (cell cycle)
GO:0007155 (cell adhesion)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007399 (nervous system development)
GO:0015031 (protein transport)
GO:0016192 (vesicle-mediated transport)
GO:0030154 (cell differentiation)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0030866 (cortical actin cytoskeleton organization)
GO:0031529 (ruffle organization)
GO:0033028 (myeloid cell apoptotic process)
GO:0034394 (protein localization to cell surface)
GO:0035020 (regulation of Rac protein signal transduction)
GO:0036010 (protein localization to endosome)
GO:0048261 (negative regulation of receptor-mediated endocytosis)
GO:0051301 (cell division)
GO:0051489 (regulation of filopodium assembly)
GO:0060998 (regulation of dendritic spine development)
GO:0090004 (positive regulation of establishment of protein localization to plasma membrane)
GO:0090162 (establishment of epithelial cell polarity)
GO:0097284 (hepatocyte apoptotic process)
GO:2000171 (negative regulation of dendrite development)
Wikipedia ARF6

Target Cross References - Protein

canSAR P62330
Human Protein Atlas ENSG00000165527
IntAct P62330
Open Targets ENSG00000165527
PharmGKB PA24942
Reactome R-HSA-8854214 (TBC/RABGAPs.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
R-HSA-8875656 (MET receptor recycling.)
UniProt P26438 P62330 Q6FGZ2

Target Cross References - Domain

InterPro IPR005225 (Small_GTP-bd_dom.)
IPR006689 (Small_GTPase_ARF/SAR.)
IPR024156 (Small_GTPase_ARF.)
IPR027417 (P-loop_NTPase.)
Pfam PF00025 (Arf)

Target Cross References - Structure

PDBe 1E0S 2A5D 2A5F 2A5G 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX
CREDO 1E0S 2A5D 2A5F 2A5G 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX
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