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Target Report Card

Target Name and Classification

Target ID CHEMBL5984
Preferred Name Apolipoprotein A-I
Synonyms APOA1 | Apo-AI | ApoA-I | Apolipoprotein A-I | Apolipoprotein A-I(1-242) | Apolipoprotein A1 | ProapoA-I | Proapolipoprotein A-I | Truncated apolipoprotein A-I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Apolipoprotein A-I SINGLE PROTEIN P02647

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118137
Ensembl ENSG00000118137
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005769 (early endosome)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0030139 (endocytic vesicle)
GO:0031012 (extracellular matrix)
GO:0031410 (cytoplasmic vesicle)
GO:0034361 (very-low-density lipoprotein particle)
GO:0034362 (low-density lipoprotein particle)
GO:0034363 (intermediate-density lipoprotein particle)
GO:0034364 (high-density lipoprotein particle)
GO:0034365 (discoidal high-density lipoprotein particle)
GO:0034366 (spherical high-density lipoprotein particle)
GO:0034774 (secretory granule lumen)
GO:0042627 (chylomicron)
GO:0070062 (extracellular exosome)
GO:0071682 (endocytic vesicle lumen)
GO:0072562 (blood microparticle)
GO:1903561 (extracellular vesicle)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0005319 (lipid transporter activity)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0005548 (phospholipid transporter activity)
GO:0008035 (high-density lipoprotein particle binding)
GO:0008289 (lipid binding)
GO:0015485 (cholesterol binding)
GO:0017127 (cholesterol transporter activity)
GO:0019899 (enzyme binding)
GO:0031072 (heat shock protein binding)
GO:0031210 (phosphatidylcholine binding)
GO:0034190 (apolipoprotein receptor binding)
GO:0034191 (apolipoprotein A-I receptor binding)
GO:0042802 (identical protein binding)
GO:0045499 (chemorepellent activity)
GO:0055102 (lipase inhibitor activity)
GO:0060228 (phosphatidylcholine-sterol O-acyltransferase activator activity)
GO:0070653 (high-density lipoprotein particle receptor binding)
GO:0071813 (lipoprotein particle binding)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0001932 (regulation of protein phosphorylation)
GO:0001935 (endothelial cell proliferation)
GO:0002576 (platelet degranulation)
GO:0002740 (negative regulation of cytokine secretion involved in immune response)
GO:0006629 (lipid metabolic process)
GO:0006644 (phospholipid metabolic process)
GO:0006656 (phosphatidylcholine biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006869 (lipid transport)
GO:0006898 (receptor-mediated endocytosis)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007584 (response to nutrient)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008211 (glucocorticoid metabolic process)
GO:0010804 (negative regulation of tumor necrosis factor-mediated signaling pathway)
GO:0010873 (positive regulation of cholesterol esterification)
GO:0010898 (positive regulation of triglyceride catabolic process)
GO:0010903 (negative regulation of very-low-density lipoprotein particle remodeling)
GO:0014012 (peripheral nervous system axon regeneration)
GO:0015914 (phospholipid transport)
GO:0018158 (protein oxidation)
GO:0018206 (peptidyl-methionine modification)
GO:0019216 (regulation of lipid metabolic process)
GO:0019433 (triglyceride catabolic process)
GO:0019915 (lipid storage)
GO:0030300 (regulation of intestinal cholesterol absorption)
GO:0030301 (cholesterol transport)
GO:0030325 (adrenal gland development)
GO:0031100 (organ regeneration)
GO:0031102 (neuron projection regeneration)
GO:0032489 (regulation of Cdc42 protein signal transduction)
GO:0033344 (cholesterol efflux)
GO:0033700 (phospholipid efflux)
GO:0034115 (negative regulation of heterotypic cell-cell adhesion)
GO:0034371 (chylomicron remodeling)
GO:0034375 (high-density lipoprotein particle remodeling)
GO:0034378 (chylomicron assembly)
GO:0034380 (high-density lipoprotein particle assembly)
GO:0034384 (high-density lipoprotein particle clearance)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0042157 (lipoprotein metabolic process)
GO:0042158 (lipoprotein biosynthetic process)
GO:0042493 (response to drug)
GO:0042632 (cholesterol homeostasis)
GO:0043534 (blood vessel endothelial cell migration)
GO:0043627 (response to estrogen)
GO:0043687 (post-translational protein modification)
GO:0043691 (reverse cholesterol transport)
GO:0044267 (cellular protein metabolic process)
GO:0045723 (positive regulation of fatty acid biosynthetic process)
GO:0050713 (negative regulation of interleukin-1 beta secretion)
GO:0050728 (negative regulation of inflammatory response)
GO:0050821 (protein stabilization)
GO:0050919 (negative chemotaxis)
GO:0051006 (positive regulation of lipoprotein lipase activity)
GO:0051180 (vitamin transport)
GO:0051345 (positive regulation of hydrolase activity)
GO:0051346 (negative regulation of hydrolase activity)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0055085 (transmembrane transport)
GO:0055091 (phospholipid homeostasis)
GO:0060192 (negative regulation of lipase activity)
GO:0060354 (negative regulation of cell adhesion molecule production)
GO:0060761 (negative regulation of response to cytokine stimulus)
GO:0070328 (triglyceride homeostasis)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070508 (cholesterol import)
GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading)
Wikipedia Apolipoprotein_A1

Target Cross References - Protein

canSAR P02647
CGD Hypoalphalipoproteinemia; Amyloidosis, systemic nonneuronopathic
Human Protein Atlas ENSG00000118137
IntAct P02647
Open Targets ENSG00000118137
PharmGKB PA49
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-1369062 (ABC transporters in lipid homeostasis.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2168880 (Scavenging of heme from plasma.)
R-HSA-3000471 (Scavenging by Class B Receptors.)
R-HSA-3000480 (Scavenging by Class A Receptors.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-8957275 (Post-translational protein phosphorylation.)
R-HSA-8963888 (Chylomicron assembly.)
R-HSA-8963896 (HDL assembly.)
R-HSA-8963901 (Chylomicron remodeling.)
R-HSA-8964011 (HDL clearance.)
R-HSA-8964058 (HDL remodeling.)
R-HSA-975634 (Retinoid metabolism and transport.)
R-HSA-977225 (Amyloid fiber formation.)
UniProt A8K866 P02647 Q6LDN9 Q6Q785 Q9UCS8 Q9UCT8

Target Cross References - Domain

InterPro IPR000074 (ApoA_E.)
Pfam PF01442 (Apolipoprotein)

Target Cross References - Structure

PDBe 1AV1 2A01 3R2P
CREDO 1AV1 2A01 3R2P