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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5984
Target Type SINGLE PROTEIN
Preferred Name Apolipoprotein A-I
Synonyms APOA1 | Apo-AI | ApoA-I | Apolipoprotein A-I | Apolipoprotein A-I(1-242) | Apolipoprotein A1 | ProapoA-I | Proapolipoprotein A-I | Truncated apolipoprotein A-I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Apolipoprotein A-I SINGLE PROTEIN P02647

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118137
Ensembl ENSG00000118137
GO Cellular Component GO:0005788 (endoplasmic reticulum lumen)
GO:0005886 (plasma membrane)
GO:0030139 (endocytic vesicle)
GO:0030141 (stored secretory granule)
GO:0034361 (very-low-density lipoprotein particle)
GO:0034366 (spherical high-density lipoprotein particle)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0005543 (phospholipid binding)
GO:0015485 (cholesterol binding)
GO:0017127 (cholesterol transporter activity)
GO:0019899 (enzyme binding)
GO:0034191 (apolipoprotein A-I receptor binding)
GO:0042802 (identical protein binding)
GO:0060228 (phosphatidylcholine-sterol O-acyltransferase activator activity)
GO:0070653 (high-density lipoprotein particle receptor binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0002740 (negative regulation of cytokine secretion involved in immune response)
GO:0006656 (phosphatidylcholine biosynthetic process)
GO:0007186 (G-protein coupled receptor protein signaling pathway)
GO:0010873 (positive regulation of cholesterol esterification)
GO:0010903 (negative regulation of very-low-density lipoprotein particle remodeling)
GO:0030168 (platelet activation)
GO:0032488 (Cdc42 protein signal transduction)
GO:0033344 (cholesterol efflux)
GO:0033700 (phospholipid efflux)
GO:0034380 (high-density lipoprotein particle assembly)
GO:0042632 (cholesterol homeostasis)
GO:0043691 (reverse cholesterol transport)
GO:0050713 (negative regulation of interleukin-1 beta secretion)
GO:0050821 (protein stabilization)
GO:0051345 (positive regulation of hydrolase activity)
GO:0070508 (cholesterol import)
Wikipedia Apolipoprotein_A1

Target Cross References - Protein

canSAR P02647
CGD Hypoalphalipoproteinemia; Amyloidosis, systemic nonneuronopathic
Human Protein Atlas ENSG00000118137
IntAct P02647
PharmGKB PA49
Reactome REACT_15518 (Transmembrane transport of small molecules.)
REACT_22258 (Metabolism of lipids and lipoproteins.)
REACT_604 (Hemostasis.)
UniProt A8K866 P02647 Q6LDN9 Q6Q785 Q9UCS8 Q9UCT8

Target Cross References - Domain

InterPro IPR000074 (ApoA1_A4_E.)
IPR013326 (ApoA/E_ApoLp.)
Pfam PF01442 (Apolipoprotein)

Target Cross References - Structure

PDBe 1AV1 2A01
CREDO 1AV1 2A01
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