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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5983
Target Type SINGLE PROTEIN
Preferred Name Aldo-keto reductase family 1 member B10
Synonyms AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldo-keto reductase family 1 member B10 SINGLE PROTEIN O60218

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198074
Ensembl ENSG00000198074
GO Cellular Component GO:0005576 (extracellular region)
GO:0005764 (lysosome)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001758 (retinal dehydrogenase activity)
GO:0004033 (aldo-keto reductase (NADP) activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0045550 (geranylgeranyl reductase activity)
GO:0047718 (indanol dehydrogenase activity)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006081 (cellular aldehyde metabolic process)
GO:0007586 (digestion)
GO:0008202 (steroid metabolic process)
GO:0016488 (farnesol catabolic process)
GO:0044597 (daunorubicin metabolic process)
GO:0044598 (doxorubicin metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia AKR1B10

Target Cross References - Protein

Human Protein Atlas ENSG00000198074
IntAct O60218
Open Targets ENSG00000198074
PharmGKB PA24676
Reactome R-HSA-975634 (Retinoid metabolism and transport.)
UniProt A4D1P1 O60218 O75890 Q6FHF3 Q8IWZ1

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 1ZUA 4GA8 4GAB 4GQ0 4GQG 4I5X 4ICC 4JIH 4JII 4WEV 4XZL 4XZM 4XZN 5LIK 5LIU 5LIW 5LIX 5LIY
CREDO 1ZUA 4GA8 4GAB 4GQ0 4GQG 4I5X 4ICC 4JIH 4JII 4WEV 4XZL 4XZM 4XZN 5LIK 5LIU 5LIW 5LIX 5LIY
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