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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5979
Target Type SINGLE PROTEIN
Preferred Name Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | TNSALP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alkaline phosphatase, tissue-nonspecific isozyme SINGLE PROTEIN P05186

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162551
Ensembl ENSG00000162551
GO Cellular Component GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031225 (anchored component of membrane)
GO:0065010 (extracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004035 (alkaline phosphatase activity)
GO:0005515 (protein binding)
GO:0016462 (pyrophosphatase activity)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001649 (osteoblast differentiation)
GO:0001958 (endochondral ossification)
GO:0003006 (developmental process involved in reproduction)
GO:0008152 (metabolic process)
GO:0016311 (dephosphorylation)
GO:0031214 (biomineral tissue development)
GO:0032496 (response to lipopolysaccharide)
GO:0033280 (response to vitamin D)
GO:0046677 (response to antibiotic)
GO:0051384 (response to glucocorticoid)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071529 (cementum mineralization)
Wikipedia ALPL

Target Cross References - Protein

canSAR P05186
CGD Hypophosphatasia; Odontohypophosphatasia
Human Protein Atlas ENSG00000162551
IntAct P05186
Open Targets ENSG00000162551
PharmGKB PA24729
Reactome R-HSA-163125 (Post-translational modification: synthesis of GPI-anchored proteins.)
UniProt A1A4E7 B2RMP8 B7Z387 B7Z4Y6 O75090 P05186 Q2TAI7 Q59EJ7 Q5BKZ5 Q5VTG5 Q6NZI8 Q8WU32 Q9UBK0

Target Cross References - Domain

InterPro IPR001952 (Alkaline_phosphatase.)
IPR017849 (Alkaline_Pase-like_a/b/a.)
IPR017850 (Alkaline_phosphatase_core.)
IPR018299 (Alkaline_phosphatase_AS.)
Pfam PF00245 (Alk_phosphatase)
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