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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5970
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase 3
Synonyms MAP3K3 | MAPK/ERK kinase kinase 3 | MAPKKK3 | MEK kinase 3 | MEKK 3 | MEKK3 | Mitogen-activated protein kinase kinase kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family > ste protein kinase mekk2

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 3 SINGLE PROTEIN Q99759

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198909
Ensembl ENSG00000198909
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPKKK cascade)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0046777 (protein autophosphorylation)
Wikipedia MAP3K3

Target Cross References - Protein

canSAR Q99759
Human Protein Atlas ENSG00000198909
IntAct Q99759
PharmGKB PA30599
Reactome REACT_6900 (Signaling in Immune system.)
UniProt B2RCW2 D3DU15 Q5BKZ6 Q8N3I9 Q99759

Target Cross References - Domain

InterPro IPR000270 (OPR_PB1.)
IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF00564 (PB1)

Target Cross References - Structure

PDBe 2C60 2O2V
CREDO 2C60 2O2V
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