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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5964
Target Type SINGLE PROTEIN
Preferred Name Aquaporin-4
Synonyms AQP-4 | AQP4 | Aquaporin-4 | MIWC | Mercurial-insensitive water channel | WCH4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > aquaporin > water-specific aquaporin

Target Components

Component Description Relationship Accession
Aquaporin-4 SINGLE PROTEIN P55087

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171885
Ensembl ENSG00000171885
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO Molecular Function GO:0005215 (transporter activity)
GO:0005372 (water transmembrane transporter activity)
GO:0015250 (water channel activity)
GO:0015254 (glycerol channel activity)
GO Biological Process GO:0003091 (renal water homeostasis)
GO:0006810 (transport)
GO:0006833 (water transport)
GO:0009992 (cellular water homeostasis)
GO:0015793 (glycerol transport)
GO:0034220 (ion transmembrane transport)
GO:0050891 (multicellular organismal water homeostasis)
GO:0071346 (cellular response to interferon-gamma)
Wikipedia Aquaporin_4

Target Cross References - Protein

canSAR P55087
Human Protein Atlas ENSG00000171885
IntAct P55087
Open Targets ENSG00000171885
PharmGKB PA24922
Reactome R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-432047 (Passive transport by Aquaporins.)
UniProt P55087 P78564

Target Cross References - Domain

InterPro IPR000425 (MIP.)
IPR022357 (MIP_CS.)
IPR023271 (Aquaporin-like.)
IPR034294 (Aquaporin_transptr.)
Pfam PF00230 (MIP)

Target Cross References - Structure

PDBe 3GD8
CREDO 3GD8
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