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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5964
Target Type SINGLE PROTEIN
Preferred Name Aquaporin-4
Synonyms AQP-4 | AQP4 | Aquaporin-4 | MIWC | Mercurial-insensitive water channel | WCH4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > aquaporin > water-specific aquaporin

Target Components

Component Description Relationship Accession
Aquaporin-4 SINGLE PROTEIN P55087

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171885
Ensembl ENSG00000171885
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005887 (integral to plasma membrane)
GO:0009897 (external side of plasma membrane)
GO Molecular Function GO:0015250 (water channel activity)
GO Biological Process GO:0007399 (nervous system development)
GO:0007588 (excretion)
GO:0071346 (cellular response to interferon-gamma)
Wikipedia Aquaporin_4

Target Cross References - Protein

canSAR P55087
Human Protein Atlas ENSG00000171885
Guide to Pharmacology 691 (AQP4)
PharmGKB PA24922
Reactome REACT_15518 (Transmembrane transport of small molecules.)
UniProt P55087 P78564

Target Cross References - Domain

InterPro IPR000425 (MIP.)
IPR012269 (Aquaporin.)
IPR022357 (MIP_CS.)
IPR023271 (Aquaporin-like.)
Pfam PF00230 (MIP)

Target Cross References - Structure

PDBe 3GD8
CREDO 3GD8
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