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Target Report Card

Target Name and Classification

Target ID CHEMBL5963
Preferred Name Proteinase-activated receptor 2
Synonyms Coagulation factor II receptor-like 1 | F2RL1 | G-protein coupled receptor 11 | GPR11 | PAR-2 | PAR2 | Proteinase-activated receptor 2 | Proteinase-activated receptor 2, alternate cleaved 1 | Proteinase-activated receptor 2, alternate cleaved 2 | Thrombin receptor-like 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > protease-activated receptor > protease-activated receptor

Target Components

Component Description Relationship Accession
Proteinase-activated receptor 2 SINGLE PROTEIN P55085

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164251
Ensembl ENSG00000164251
GO Cellular Component GO:0005769 (early endosome)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031143 (pseudopodium)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004872 (receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0015057 (thrombin receptor activity)
GO:0031681 (G-protein beta-subunit binding)
GO Biological Process GO:0002286 (T cell activation involved in immune response)
GO:0002376 (immune system process)
GO:0002690 (positive regulation of leukocyte chemotaxis)
GO:0002741 (positive regulation of cytokine secretion involved in immune response)
GO:0003104 (positive regulation of glomerular filtration)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007596 (blood coagulation)
GO:0010804 (negative regulation of tumor necrosis factor-mediated signaling pathway)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0030193 (regulation of blood coagulation)
GO:0030335 (positive regulation of cell migration)
GO:0030836 (positive regulation of actin filament depolymerization)
GO:0031274 (positive regulation of pseudopodium assembly)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0034137 (positive regulation of toll-like receptor 2 signaling pathway)
GO:0034140 (negative regulation of toll-like receptor 3 signaling pathway)
GO:0034141 (positive regulation of toll-like receptor 3 signaling pathway)
GO:0034145 (positive regulation of toll-like receptor 4 signaling pathway)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0035926 (chemokine (C-C motif) ligand 2 secretion)
GO:0042119 (neutrophil activation)
GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043311 (positive regulation of eosinophil degranulation)
GO:0045087 (innate immune response)
GO:0045909 (positive regulation of vasodilation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046328 (regulation of JNK cascade)
GO:0046329 (negative regulation of JNK cascade)
GO:0046330 (positive regulation of JNK cascade)
GO:0050702 (interleukin-1 beta secretion)
GO:0050900 (leukocyte migration)
GO:0050921 (positive regulation of chemotaxis)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051607 (defense response to virus)
GO:0060100 (positive regulation of phagocytosis, engulfment)
GO:0061028 (establishment of endothelial barrier)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070493 (thrombin receptor signaling pathway)
GO:0070661 (leukocyte proliferation)
GO:0070963 (positive regulation of neutrophil mediated killing of gram-negative bacterium)
GO:0072608 (interleukin-10 secretion)
GO:0072643 (interferon-gamma secretion)
GO:0090195 (chemokine secretion)
GO:0090198 (negative regulation of chemokine secretion)
GO:0097029 (mature conventional dendritic cell differentiation)
GO:1900135 (positive regulation of renin secretion into blood stream)
GO:2000484 (positive regulation of interleukin-8 secretion)
GO:2000778 (positive regulation of interleukin-6 secretion)
Wikipedia Protease_activated_receptor_2

Target Cross References - Protein

canSAR P55085
Human Protein Atlas ENSG00000164251
IntAct P55085
Guide to Pharmacology 348
Open Targets ENSG00000164251
PharmGKB PA27947
Pharos P55085 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P55085 Q13317 Q13346 Q53XJ8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002281 (Pro_rcpt_2.)
IPR003912 (Protea_act_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)