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Target Report Card

Target Name and Classification

Target ID CHEMBL5962
Preferred Name Phospholipid transfer protein
Synonyms Lipid transfer protein II | PLTP | Phospholipid transfer protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > pore-forming toxins (proteins and peptides)

Target Components

Component Description Relationship Accession
Phospholipid transfer protein SINGLE PROTEIN P55058

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100979
Ensembl ENSG00000100979
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0034364 (high-density lipoprotein particle)
GO Molecular Function GO:0005319 (lipid transporter activity)
GO:0005548 (phospholipid transporter activity)
GO:0008289 (lipid binding)
GO:0008429 (phosphatidylethanolamine binding)
GO:0008525 (phosphatidylcholine transporter activity)
GO:0019992 (diacylglycerol binding)
GO:0031210 (phosphatidylcholine binding)
GO:0035620 (ceramide transporter activity)
GO:0070300 (phosphatidic acid binding)
GO:0097001 (ceramide binding)
GO:1901611 (phosphatidylglycerol binding)
GO:1904121 (phosphatidylethanolamine transporter activity)
GO:1990050 (phosphatidic acid transporter activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006869 (lipid transport)
GO:0010189 (vitamin E biosynthetic process)
GO:0010875 (positive regulation of cholesterol efflux)
GO:0015914 (phospholipid transport)
GO:0030317 (sperm motility)
GO:0034375 (high-density lipoprotein particle remodeling)
GO:0035627 (ceramide transport)
Wikipedia Phospholipid_transfer_protein

Target Cross References - Protein

canSAR P55058
Human Protein Atlas ENSG00000100979
IntAct P55058
Open Targets ENSG00000100979
PharmGKB PA273
Reactome R-HSA-8964058 (HDL remodeling.)
UniProt A8K006 B4DDD5 B4DRB4 E1P5N8 E7EV16 P55058 Q8WTT1 Q9BR07 Q9BSH8

Target Cross References - Domain

InterPro IPR001124 (Lipid-bd_serum_glycop_C.)
IPR017942 (Lipid-bd_serum_glycop_N.)
IPR017943 (Bactericidal_perm-incr_a/b_dom.)
IPR017954 (Lipid-bd_serum_glycop_CS.)
IPR030179 (PLTP.)
IPR030675 (BPI/LBP.)
IPR032942 (BPI/LBP/Plunc.)
Pfam PF01273 (LBP_BPI_CETP)