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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5960
Target Type SINGLE PROTEIN
Preferred Name Alpha-1-antichymotrypsin
Synonyms AACT | ACT | Alpha-1-antichymotrypsin | Alpha-1-antichymotrypsin His-Pro-less | Cell growth-inhibiting gene 24/25 protein | GIG25 | SERPINA3 | Serpin A3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Alpha-1-antichymotrypsin SINGLE PROTEIN P01011

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196136
Ensembl ENSG00000196136
GO Cellular Component GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0070062 (extracellular exosome)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004867 (serine-type endopeptidase inhibitor activity)
GO:0003677 (DNA binding)
GO Biological Process GO:0030277 (maintenance of gastrointestinal epithelium)
GO:0006954 (inflammatory response)
GO:0006953 (acute-phase response)
GO:0010951 (negative regulation of endopeptidase activity)
GO:0019216 (regulation of lipid metabolic process)
Wikipedia Alpha_1-antichymotrypsin

Target Cross References - Protein

canSAR P01011
Human Protein Atlas ENSG00000196136
IntAct P01011
PharmGKB PA35020
UniProt B3KVQ7 Q9UNU9 Q59GP9 Q6LDT7 Q9UC47 Q6LBY8 Q13703 Q6NSC9 Q2TU88 Q8N177 P01011 Q2TU87 Q96DW8

Target Cross References - Domain

InterPro IPR000215 (Serpin_fam.)
IPR023796 (Serpin_dom.)
IPR023795 (Serpin_CS.)
Pfam PF00079 (Serpin)

Target Cross References - Structure

PDBe 2ACH 3CAA 1AS4 4CAA 1QMN 3DLW
CREDO 2ACH 3CAA 1AS4 4CAA 1QMN 3DLW
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