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Target Report Card

Target Name and Classification

Target ID CHEMBL5953
Target Type SINGLE PROTEIN
Preferred Name RAS guanyl-releasing protein 1
Synonyms CalDAG-GEFII | Calcium and DAG-regulated guanine nucleotide exchange factor II | RAS guanyl-releasing protein 1 | RASGRP | RASGRP1 | Ras guanyl-releasing protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
RAS guanyl-releasing protein 1 SINGLE PROTEIN O95267

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172575
Ensembl ENSG00000172575
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0042629 (mast cell granule)
GO Molecular Function GO:0001786 (phosphatidylserine binding)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005096 (GTPase activator activity)
GO:0005509 (calcium ion binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0019992 (diacylglycerol binding)
GO:0031210 (phosphatidylcholine binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001816 (cytokine production)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002437 (inflammatory response to antigenic stimulus)
GO:0007165 (signal transduction)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007265 (Ras protein signal transduction)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0030154 (cell differentiation)
GO:0032252 (secretory granule localization)
GO:0032725 (positive regulation of granulocyte macrophage colony-stimulating factor production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032816 (positive regulation of natural killer cell activation)
GO:0032825 (positive regulation of natural killer cell differentiation)
GO:0033089 (positive regulation of T cell differentiation in thymus)
GO:0035556 (intracellular signal transduction)
GO:0043087 (regulation of GTPase activity)
GO:0043303 (mast cell degranulation)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0045954 (positive regulation of natural killer cell mediated cytotoxicity)
GO:0046330 (positive regulation of JNK cascade)
GO:0046579 (positive regulation of Ras protein signal transduction)
GO:0047496 (vesicle transport along microtubule)
GO:0051259 (protein oligomerization)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090630 (activation of GTPase activity)
GO:1900274 (regulation of phospholipase C activity)
GO:1900744 (regulation of p38MAPK cascade)
GO:1902715 (positive regulation of interferon-gamma secretion)
Wikipedia RASGRP1

Target Cross References - Protein

canSAR O95267
Human Protein Atlas ENSG00000172575
IntAct O95267
Open Targets ENSG00000172575
PharmGKB PA34240
Reactome R-HSA-114508 (Effects of PIP2 hydrolysis.)
R-HSA-1169092 (Activation of RAS in B cells.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-354192 (Integrin alphaIIb beta3 signaling.)
R-HSA-392517 (Rap1 signalling.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
UniProt O95267 Q56CZ0 Q58G75 Q59HB1 Q5I3A8 Q6GV31 Q6NX39 Q7LDG6 Q9UI94 Q9UNN9

Target Cross References - Domain

InterPro IPR000651 (Ras-like_Gua-exchang_fac_N.)
IPR001895 (RASGEF_cat_dom.)
IPR002048 (EF_hand_dom.)
IPR002219 (PE/DAG-bd.)
IPR011992 (EF-hand-dom_pair.)
IPR018247 (EF_Hand_1_Ca_BS.)
IPR020454 (DAG/PE-bd.)
IPR023578 (Ras_GEF_dom_sf.)
IPR029645 (RASGRP1/RASGRP3.)
IPR036964 (RASGEF_cat_dom_sf.)
Pfam PF00130 (C1_1)
PF00617 (RasGEF)
PF00618 (RasGEF_N)

Target Cross References - Structure

PDBe 4L9M 4L9U
CREDO 4L9M 4L9U
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