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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5942
Target Type SINGLE PROTEIN
Preferred Name Phosphatidylcholine-sterol acyltransferase
Synonyms LCAT | Lecithin-cholesterol acyltransferase | Phosphatidylcholine-sterol acyltransferase | Phospholipid-cholesterol acyltransferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylcholine-sterol acyltransferase SINGLE PROTEIN P04180

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213398
Ensembl ENSG00000213398
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0034364 (high-density lipoprotein particle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity)
GO:0004623 (phospholipase A2 activity)
GO:0005515 (protein binding)
GO:0008374 (O-acyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0034186 (apolipoprotein A-I binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006644 (phospholipid metabolic process)
GO:0006656 (phosphatidylcholine biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0030301 (cholesterol transport)
GO:0034372 (very-low-density lipoprotein particle remodeling)
GO:0034375 (high-density lipoprotein particle remodeling)
GO:0034435 (cholesterol esterification)
GO:0042157 (lipoprotein metabolic process)
GO:0042158 (lipoprotein biosynthetic process)
GO:0042632 (cholesterol homeostasis)
GO:0043691 (reverse cholesterol transport)
GO:0046470 (phosphatidylcholine metabolic process)
GO:0046688 (response to copper ion)
GO:0051384 (response to glucocorticoid)
GO:0090107 (regulation of high-density lipoprotein particle assembly)
Wikipedia Lecithin%E2%80%94cholesterol_acyltransferase

Target Cross References - Protein

canSAR P04180
CGD Lecithin:cholesterol acyltransferase deficiency; Fish-eye disease
Human Protein Atlas ENSG00000213398
IntAct P04180
Open Targets ENSG00000213398
PharmGKB PA226
Reactome R-HSA-194223 (HDL-mediated lipid transport.)
UniProt P04180 Q53XQ3

Target Cross References - Domain

InterPro IPR003386 (LACT/PDAT_acylTrfase.)
IPR029058 (AB_hydrolase.)
Pfam PF02450 (LCAT)

Target Cross References - Structure

PDBe 4X96 4XWG 4XX1 5BV7
CREDO 4X96 4XWG 4XX1 5BV7
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