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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5941
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase MST4
Synonyms MASK | MST-4 | MST3 and SOK1-related kinase | MST4 | Mammalian STE20-like protein kinase 4 | STE20-like kinase MST4 | STK26 | Serine/threonine-protein kinase 26 | Serine/threonine-protein kinase MASK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase ysk subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase 26 SINGLE PROTEIN Q9P289

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134602
Ensembl ENSG00000134602
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005798 (Golgi-associated vesicle)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0016324 (apical plasma membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0071944 (cell periphery)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006921 (cellular component disassembly involved in apoptosis)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0007346 (regulation of mitotic cell cycle)
GO:0012501 (programmed cell death)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030033 (microvillus assembly)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0032147 (activation of protein kinase activity)
GO:0042542 (response to hydrogen peroxide)
GO:0042981 (regulation of apoptosis)
GO:0042981 (regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:1903205 (regulation of hydrogen peroxide-induced cell death)
Wikipedia MST4 RP6-213H19.1

Target Cross References - Protein

canSAR Q9P289
Human Protein Atlas ENSG00000134602
IntAct Q9P289
UniProt B2RAU2 Q3ZB77 Q8NC04 Q9BXC3 Q9BXC4 Q9P289

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3GGF 3W8I 4FZA 4FZD 4FZF 4GEH
CREDO 3GGF 3W8I 4FZA 4FZD 4FZF 4GEH
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