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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5940
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase MARK1
Synonyms KIAA1477 | MAP/microtubule affinity-regulating kinase 1 | MARK | MARK1 | PAR1 homolog c | Par-1c | Par1c | Serine/threonine-protein kinase MARK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase mark subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase MARK1 SINGLE PROTEIN Q9P0L2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116141
Ensembl ENSG00000116141
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0001786 (phosphatidylserine binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding)
GO:0008289 (lipid binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0050321 (tau-protein kinase activity)
GO:0070300 (phosphatidic acid binding)
GO Biological Process GO:0001764 (neuron migration)
GO:0006468 (protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0035556 (intracellular signal transduction)
Wikipedia MARK1

Target Cross References - Protein

canSAR Q9P0L2
Human Protein Atlas ENSG00000116141
IntAct Q9P0L2
Guide to Pharmacology 2097
Open Targets ENSG00000116141
PharmGKB PA30639
Pharos Q9P0L2 (Tchem)
UniProt D3DTB0 D3DTB1 Q2HIY1 Q5VTF9 Q5VTG0 Q96SW9 Q9P0L2 Q9P251

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001772 (KA1_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015940 (UBA.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
Pfam PF00069 (Pkinase)
PF00627 (UBA)
PF02149 (KA1)

Target Cross References - Structure

PDBe 2HAK 3OSE
CREDO 2HAK 3OSE
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