ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5939
Target Type SINGLE PROTEIN
Preferred Name Endoplasmic reticulum aminopeptidase 1
Synonyms A-LAP | APPILS | ARTS-1 | ARTS1 | Adipocyte-derived leucine aminopeptidase | Aminopeptidase PILS | ERAP1 | Endoplasmic reticulum aminopeptidase 1 | KIAA0525 | PILS-AP | Puromycin-insensitive leucyl-specific aminopeptidase | Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Endoplasmic reticulum aminopeptidase 1 SINGLE PROTEIN Q9NZ08

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164307
Ensembl ENSG00000164307
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004177 (aminopeptidase activity)
GO:0005138 (interleukin-6 receptor binding)
GO:0005151 (interleukin-1, Type II receptor binding)
GO:0005164 (tumor necrosis factor receptor binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008235 (metalloexopeptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002474 (antigen processing and presentation of peptide antigen via MHC class I)
GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0008217 (regulation of blood pressure)
GO:0009617 (response to bacterium)
GO:0019885 (antigen processing and presentation of endogenous peptide antigen via MHC class I)
GO:0043171 (peptide catabolic process)
GO:0045088 (regulation of innate immune response)
GO:0045444 (fat cell differentiation)
GO:0045766 (positive regulation of angiogenesis)
Wikipedia ARTS-1

Target Cross References - Protein

canSAR Q9NZ08
Human Protein Atlas ENSG00000164307
IntAct Q9NZ08
Guide to Pharmacology 1566
Open Targets ENSG00000164307
PharmGKB PA162385163
Reactome R-HSA-983170 (Antigen Presentation: Folding, assembly and peptide loading of class I MHC.)
UniProt O60278 Q6UWY6 Q8NEL4 Q8TAD0 Q9NZ08 Q9UHF8 Q9UKY2

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR024571 (ERAP1-like_C_dom.)
IPR033520 (ERAP1.)
IPR034016 (M1_APN-typ.)
Pfam PF01433 (Peptidase_M1)
PF11838 (ERAP1_C)

Target Cross References - Structure

PDBe 2YD0 3MDJ 3QNF 3RJO
CREDO 2YD0 3MDJ 3QNF 3RJO
spacer
spacer