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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5939
Target Type SINGLE PROTEIN
Preferred Name Endoplasmic reticulum aminopeptidase 1
Synonyms A-LAP | APPILS | ARTS-1 | ARTS1 | Adipocyte-derived leucine aminopeptidase | Aminopeptidase PILS | ERAP1 | Endoplasmic reticulum aminopeptidase 1 | KIAA0525 | PILS-AP | Puromycin-insensitive leucyl-specific aminopeptidase | Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Endoplasmic reticulum aminopeptidase 1 SINGLE PROTEIN Q9NZ08

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164307
Ensembl ENSG00000164307
GO Cellular Component GO:0005576 (extracellular region)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0005138 (interleukin-6 receptor binding)
GO:0005151 (interleukin-1, Type II receptor binding)
GO:0008235 (metalloexopeptidase activity)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0008217 (regulation of blood pressure)
GO:0009617 (response to bacterium)
GO:0019885 (antigen processing and presentation of endogenous peptide antigen via MHC class I)
GO:0045088 (regulation of innate immune response)
GO:0045444 (fat cell differentiation)
Wikipedia ARTS-1

Target Cross References - Protein

canSAR Q9NZ08
Human Protein Atlas ENSG00000164307
IntAct Q9NZ08
Guide to Pharmacology 1566 (Endoplasmic reticulum aminopeptidase 1)
PharmGKB PA162385163
UniProt O60278 Q6UWY6 Q8NEL4 Q8TAD0 Q9NZ08 Q9UHF8 Q9UKY2

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
Pfam PF01433 (Peptidase_M1)

Target Cross References - Structure

PDBe 2YD0 3MDJ 3QNF
CREDO 2YD0 3MDJ 3QNF
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