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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5936
Target Type SINGLE PROTEIN
Preferred Name Toll-like receptor 7
Synonyms TLR7 | Toll-like receptor 7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > toll-like and il-1 receptors

Target Components

Component Description Relationship Accession
Toll-like receptor 7 SINGLE PROTEIN Q9NYK1

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137288 TLR7 and TLR8 PROTEIN FAMILY
CHEMBL2111471 Toll-like receptor (TLR7/TLR9) PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1282 IMIQUIMOD Toll-like receptor 7 agonist 4 FDA PubMed
CHEMBL1690 HYDROXYCHLOROQUINE SULFATE Toll-like receptor 7 antagonist 4 DailyMed FDA PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196664
Ensembl ENSG00000196664
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0032009 (early phagosome)
GO:0036020 (endolysosome membrane)
GO:0043235 (receptor complex)
GO:0045335 (phagocytic vesicle)
GO Molecular Function GO:0003725 (double-stranded RNA binding)
GO:0003727 (single-stranded RNA binding)
GO:0004872 (receptor activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0008144 (drug binding)
GO:0035197 (siRNA binding)
GO Biological Process GO:0001774 (microglial cell activation)
GO:0001932 (regulation of protein phosphorylation)
GO:0002224 (toll-like receptor signaling pathway)
GO:0002376 (immune system process)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007252 (I-kappaB phosphorylation)
GO:0032722 (positive regulation of chemokine production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0034154 (toll-like receptor 7 signaling pathway)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0045078 (positive regulation of interferon-gamma biosynthetic process)
GO:0045087 (innate immune response)
GO:0045356 (positive regulation of interferon-alpha biosynthetic process)
GO:0045359 (positive regulation of interferon-beta biosynthetic process)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0050729 (positive regulation of inflammatory response)
GO:0051607 (defense response to virus)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia TLR_7

Target Cross References - Protein

canSAR Q9NYK1
Human Protein Atlas ENSG00000196664
IntAct Q9NYK1
Guide to Pharmacology 1757
Open Targets ENSG00000196664
PharmGKB PA38008
Reactome R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-168181 (Toll Like Receptor 7/8 (TLR7/8) Cascade.)
R-HSA-975110 (TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.)
R-HSA-975138 (TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.)
R-HSA-975155 (MyD88 dependent cascade initiated on endosome.)
UniProt D1CS69 Q9NR98 Q9NYK1

Target Cross References - Domain

InterPro IPR000157 (TIR_dom.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR026880 (TLR7.)
IPR026906 (LRR_5.)
IPR032675 (L_dom-like.)
Pfam PF00560 (LRR_1)
PF01582 (TIR)
PF13306 (LRR_5)
PF13855 (LRR_8)
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