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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5932
Target Type SINGLE PROTEIN
Preferred Name LIM domain kinase 2
Synonyms LIM domain kinase 2 | LIMK-2 | LIMK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase lisk family > tkl protein kinase limk subfamily

Target Components

Component Description Relationship Accession
LIM domain kinase 2 SINGLE PROTEIN P53671

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182541
Ensembl ENSG00000182541
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005801 (cis-Golgi network)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007283 (spermatogenesis)
GO:0016310 (phosphorylation)
Wikipedia LIMK2

Target Cross References - Protein

canSAR P53671
Human Protein Atlas ENSG00000182541
IntAct P53671
Guide to Pharmacology 2055
Open Targets ENSG00000182541
PharmGKB PA30387
Pharos P53671 (Tchem)
Reactome R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-416572 (Sema4D induced cell migration and growth-cone collapse.)
R-HSA-5627117 (RHO GTPases Activate ROCKs.)
UniProt A8K6H5 P53671 Q7KZ80 Q7L3H5 Q96E10 Q99464 Q9UFU0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001478 (PDZ.)
IPR001781 (Znf_LIM.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00412 (LIM)
PF00595 (PDZ)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 4TPT
CREDO 4TPT
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