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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5930
Target Type SINGLE PROTEIN
Preferred Name Corticotropin-releasing factor-binding protein
Synonyms CRF-BP | CRF-binding protein | CRFBP | CRH-BP | CRHBP | Corticotropin-releasing factor-binding protein | Corticotropin-releasing hormone-binding protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Corticotropin-releasing factor-binding protein SINGLE PROTEIN P24387

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885546 Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145708
Ensembl ENSG00000145708
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005767 (secondary lysosome)
GO:0005771 (multivesicular body)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005874 (microtubule)
GO:0030141 (secretory granule)
GO:0030425 (dendrite)
GO:0031045 (dense core granule)
GO:0043196 (varicosity)
GO:0043204 (perikaryon)
GO:0043679 (axon terminus)
GO Molecular Function GO:0005515 (protein binding)
GO:0042277 (peptide binding)
GO:0051424 (corticotropin-releasing hormone binding)
GO Biological Process GO:0001963 (synaptic transmission, dopaminergic)
GO:0002125 (maternal aggressive behavior)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007565 (female pregnancy)
GO:0007611 (learning or memory)
GO:0009755 (hormone-mediated signaling pathway)
GO:0035690 (cellular response to drug)
GO:0035865 (cellular response to potassium ion)
GO:0042445 (hormone metabolic process)
GO:0045055 (regulated exocytosis)
GO:0048149 (behavioral response to ethanol)
GO:0051459 (regulation of corticotropin secretion)
GO:0051460 (negative regulation of corticotropin secretion)
GO:0071277 (cellular response to calcium ion)
GO:0071314 (cellular response to cocaine)
GO:0071320 (cellular response to cAMP)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071391 (cellular response to estrogen stimulus)
GO:0071392 (cellular response to estradiol stimulus)
GO:0080135 (regulation of cellular response to stress)
GO:0097211 (cellular response to gonadotropin-releasing hormone)
GO:1900011 (negative regulation of corticotropin-releasing hormone receptor activity)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)
Wikipedia CRHBP

Target Cross References - Protein

canSAR P24387
Human Protein Atlas ENSG00000145708
Open Targets ENSG00000145708
PharmGKB PA26873
Reactome R-HSA-373080 (Class B/2 (Secretin family receptors).)
UniProt P24387 Q53F32 Q6FHT5

Target Cross References - Domain

InterPro IPR008435 (CRF-bd.)
IPR035914 (Sperma_CUB_dom_sf.)
Pfam PF05428 (CRF-BP)
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