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Target Report Card

Target Name and Classification

Target ID CHEMBL5925
Preferred Name Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Synonyms Alkaline phosphodiesterase I | E-NPP 1 | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | M6S1 | Membrane component chromosome 6 surface marker 1 | NPPS | NPPase | Nucleotide diphosphatase | Nucleotide pyrophosphatase | PC1 | PDNP1 | Phosphodiesterase I/nucleotide pyrophosphatase 1 | Plasma-cell membrane glycoprotein PC-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 SINGLE PROTEIN P22413

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197594
Ensembl ENSG00000197594
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005765 (lysosomal membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO Molecular Function GO:0003676 (nucleic acid binding)
GO:0003824 (catalytic activity)
GO:0004528 (phosphodiesterase I activity)
GO:0004551 (nucleotide diphosphatase activity)
GO:0005044 (scavenger receptor activity)
GO:0005158 (insulin receptor binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0030247 (polysaccharide binding)
GO:0035529 (NADH pyrophosphatase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0047429 (nucleoside-triphosphate diphosphatase activity)
GO:0050656 (3'-phosphoadenosine 5'-phosphosulfate binding)
GO Biological Process GO:0006091 (generation of precursor metabolites and energy)
GO:0006771 (riboflavin metabolic process)
GO:0006796 (phosphate-containing compound metabolic process)
GO:0006898 (receptor-mediated endocytosis)
GO:0006955 (immune response)
GO:0008152 (metabolic process)
GO:0009143 (nucleoside triphosphate catabolic process)
GO:0030308 (negative regulation of cell growth)
GO:0030500 (regulation of bone mineralization)
GO:0030505 (inorganic diphosphate transport)
GO:0030643 (cellular phosphate ion homeostasis)
GO:0030730 (sequestering of triglyceride)
GO:0031214 (biomineral tissue development)
GO:0031953 (negative regulation of protein autophosphorylation)
GO:0032869 (cellular response to insulin stimulus)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045719 (negative regulation of glycogen biosynthetic process)
GO:0046325 (negative regulation of glucose import)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0050427 (3'-phosphoadenosine 5'-phosphosulfate metabolic process)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
Wikipedia Ectonucleotide_pyrophosphatase/phosphodiesterase_1

Target Cross References - Protein

canSAR P22413
CGD Hypophosphatemic rickets, autosomal recessive 2; Arterial calcification, generalized, of infancy, 1
Human Protein Atlas ENSG00000197594
IntAct P22413
Open Targets ENSG00000197594
PharmGKB PA27791
Reactome R-HSA-196843 (Vitamin B2 (riboflavin) metabolism.)
R-HSA-199220 (Vitamin B5 (pantothenate) metabolism.)
UniProt P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3

Target Cross References - Domain

InterPro IPR001212 (Somatomedin_B_dom.)
IPR001604 (DNA/RNA_non-sp_Endonuclease.)
IPR002591 (Phosphodiest/P_Trfase.)
IPR017849 (Alkaline_Pase-like_a/b/a.)
IPR017850 (Alkaline_phosphatase_core.)
IPR020436 (Somatomedin_B_chordata.)
IPR020821 (Extracellular_endonuc_su_A.)
IPR029890 (ENPP1.)
Pfam PF01033 (Somatomedin_B)
PF01223 (Endonuclease_NS)
PF01663 (Phosphodiest)