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Target Report Card

Target Name and Classification

Target ID CHEMBL5919
Preferred Name Myeloid differentiation primary response protein MyD88
Synonyms MYD88 | Myeloid differentiation primary response protein MyD88
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Myeloid differentiation primary response protein MyD88 SINGLE PROTEIN Q99836

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172936
Ensembl ENSG00000172936
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO Molecular Function GO:0005123 (death receptor binding)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO:0043621 (protein self-association)
GO:0070976 (TIR domain binding)
GO Biological Process GO:0002224 (toll-like receptor signaling pathway)
GO:0002376 (immune system process)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0010628 (positive regulation of gene expression)
GO:0032481 (positive regulation of type I interferon production)
GO:0032740 (positive regulation of interleukin-17 production)
GO:0032747 (positive regulation of interleukin-23 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045087 (innate immune response)
GO:0050727 (regulation of inflammatory response)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0060337 (type I interferon signaling pathway)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0070555 (response to interleukin-1)
GO:0070935 (3'-UTR-mediated mRNA stabilization)
GO:0071260 (cellular response to mechanical stimulus)
GO:0140052 (cellular response to oxidised low-density lipoprotein particle stimulus)
GO:1900017 (positive regulation of cytokine production involved in inflammatory response)
Wikipedia MYD88

Target Cross References - Protein

canSAR Q99836
CGD MYD88 deficiency
Human Protein Atlas ENSG00000172936
IntAct Q99836
Open Targets ENSG00000172936
PharmGKB PA31361
Reactome R-HSA-1236974 (ER-Phagosome pathway.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-166058 (MyD88:Mal cascade initiated on plasma membrane.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-209543 (p75NTR recruits signalling complexes.)
R-HSA-3134963 (DEx/H-box helicases activate type I IFN and inflammatory cytokines production.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-5602498 (MyD88 deficiency (TLR2/4).)
R-HSA-5602680 (MyD88 deficiency (TLR5).)
R-HSA-5603037 (IRAK4 deficiency (TLR5).)
R-HSA-5603041 (IRAK4 deficiency (TLR2/4).)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-9020702 (Interleukin-1 signaling.)
R-HSA-933541 (TRAF6 mediated IRF7 activation.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
R-HSA-975110 (TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.)
R-HSA-975138 (TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.)
R-HSA-975155 (MyD88 dependent cascade initiated on endosome.)
R-HSA-975871 (MyD88 cascade initiated on plasma membrane.)
UniProt B4DKH8 B4DKU4 B4DQ60 B4DQ72 J3KPU4 J3KQ87 J3KQJ6 P78397 Q53XS7 Q99836

Target Cross References - Domain

InterPro IPR000157 (TIR_dom.)
IPR000488 (Death_domain.)
IPR011029 (DEATH-like_dom_sf.)
IPR017281 (Myelin_different_resp_MyD88.)
IPR034249 (MyD88_Death.)
IPR035897 (Toll_tir_struct_dom_sf.)
Pfam PF00531 (Death)
PF01582 (TIR)

Target Cross References - Structure