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Target Report Card

Target Name and Classification

Target ID CHEMBL5918
Preferred Name Canalicular multispecific organic anion transporter 2
Synonyms ABCC3 | ATP-binding cassette sub-family C member 3 | CMOAT2 | Canalicular multispecific organic anion transporter 2 | MLP2 | MOAT-D | MRP3 | Multi-specific organic anion transporter D | Multidrug resistance-associated protein 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
Canalicular multispecific organic anion transporter 2 SINGLE PROTEIN O15438

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108846
Ensembl ENSG00000108846
GO Cellular Component GO:0005624 (membrane fraction)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0005524 (ATP binding)
GO:0008514 (organic anion transmembrane transporter activity)
GO:0015432 (bile acid-exporting ATPase activity)
GO Biological Process GO:0008206 (bile acid metabolic process)
Wikipedia ABCC3

Target Cross References - Protein

canSAR O15438
Human Protein Atlas ENSG00000108846
IntAct O15438
Guide to Pharmacology 781 (ABCC3)
PharmGKB PA376
Reactome REACT_22258 (Metabolism of lipids and lipoproteins.)
UniProt B2RPA9 D3DTX9 O15438 O60265 O60922 O75621 O95078 O95289 O95290 Q86X85 Q9UN52

Target Cross References - Domain

InterPro IPR001140 (ABC_transptr_TM_dom.)
IPR003439 (ABC_transporter-like.)
IPR003593 (ATPase_AAA+_core.)
IPR005292 (Multidrug-R_assoc.)
IPR011527 (ABC_transptrTM_dom_typ1.)
IPR017871 (ABC_transporter_CS.)
IPR017940 (ABC_transporter_type1.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)