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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5917
Target Type SINGLE PROTEIN
Preferred Name Malate dehydrogenase, mitochondrial
Synonyms MDH2 | Malate dehydrogenase, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Malate dehydrogenase, mitochondrial SINGLE PROTEIN P40926

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000146701
Ensembl ENSG00000146701
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005759 (mitochondrial matrix)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0043209 (myelin sheath)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0016491 (oxidoreductase activity)
GO:0016615 (malate dehydrogenase activity)
GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0030060 (L-malate dehydrogenase activity)
GO:0043621 (protein self-association)
GO:0044822 (poly(A) RNA binding)
GO:0046554 (malate dehydrogenase (NADP+) activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006094 (gluconeogenesis)
GO:0006099 (tricarboxylic acid cycle)
GO:0006107 (oxaloacetate metabolic process)
GO:0006108 (malate metabolic process)
GO:0006475 (internal protein amino acid acetylation)
GO:0006734 (NADH metabolic process)
GO:0019752 (carboxylic acid metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia Malate_dehydrogenase_2

Target Cross References - Protein

canSAR P40926
Human Protein Atlas ENSG00000146701
IntAct P40926
Open Targets ENSG00000146701
PharmGKB PA30716
Reactome R-HSA-70263 (Gluconeogenesis.)
R-HSA-71403 (Citric acid cycle (TCA cycle).)
UniProt A8K414 B2RE78 B4DE44 E9PDB2 O43682 P40926

Target Cross References - Domain

InterPro IPR001236 (Lactate/malate_DH_N.)
IPR001252 (Malate_DH_AS.)
IPR001557 (L-lactate/malate_DH.)
IPR010097 (Malate_DH_type1.)
IPR015955 (Lactate_DH/Glyco_Ohase_4_C.)
IPR016040 (NAD(P)-bd_dom.)
IPR022383 (Lactate/malate_DH_C.)
Pfam PF00056 (Ldh_1_N)
PF02866 (Ldh_1_C)

Target Cross References - Structure

PDBe 2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
CREDO 2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
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