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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5909
Target Type SINGLE PROTEIN
Preferred Name Hypoxia-inducible factor 1-alpha inhibitor
Synonyms FIH-1 | FIH1 | Factor inhibiting HIF-1 | HIF1AN | Hypoxia-inducible factor 1-alpha inhibitor | Hypoxia-inducible factor asparagine hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hypoxia-inducible factor 1-alpha inhibitor SINGLE PROTEIN Q9NWT6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166135
Ensembl ENSG00000166135
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005112 (Notch binding)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016706 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors)
GO:0019826 (oxygen sensor activity)
GO:0031406 (carboxylic acid binding)
GO:0036139 (peptidyl-histidine dioxygenase activity)
GO:0036140 (peptidyl-asparagine 3-dioxygenase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0048037 (cofactor binding)
GO:0051059 (NF-kappaB binding)
GO:0051213 (dioxygenase activity)
GO:0071532 (ankyrin repeat binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0036138 (peptidyl-histidine hydroxylation)
GO:0042264 (peptidyl-aspartic acid hydroxylation)
GO:0042265 (peptidyl-asparagine hydroxylation)
GO:0045663 (positive regulation of myoblast differentiation)
GO:0045746 (negative regulation of Notch signaling pathway)
GO:0055114 (oxidation-reduction process)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0061428 (negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:2001214 (positive regulation of vasculogenesis)
Wikipedia HIF1AN

Target Cross References - Protein

canSAR Q9NWT6
Human Protein Atlas ENSG00000166135
IntAct Q9NWT6
Open Targets ENSG00000166135
PharmGKB PA29284
Reactome R-HSA-1234162 (Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha.)
UniProt D3DR69 Q5W147 Q969Q7 Q9NPV5 Q9NWT6

Target Cross References - Domain

InterPro IPR003347 (JmjC_dom.)
IPR027445 (FIH-1.)
IPR027452 (FIH-1_domII.)

Target Cross References - Structure

PDBe 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P More...
CREDO 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P More...
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