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Target Report Card

Target Name and Classification

Target ID CHEMBL5908
Target Type SINGLE PROTEIN
Preferred Name Protection of telomeres protein 1
Synonyms POT1 | POT1-like telomere end-binding protein | Protection of telomeres protein 1 | hPot1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Protection of telomeres protein 1 SINGLE PROTEIN Q9NUX5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000128513
Ensembl ENSG00000128513
GO Cellular Component GO:0000781 (chromosome, telomeric region)
GO:0000783 (nuclear telomere cap complex)
GO:0000784 (nuclear chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0070187 (telosome)
GO Molecular Function GO:0003677 (DNA binding)
GO:0005515 (protein binding)
GO:0010521 (telomerase inhibitor activity)
GO:0017151 (DEAD/H-box RNA helicase binding)
GO:0042162 (telomeric DNA binding)
GO:0043047 (single-stranded telomeric DNA binding)
GO:0061821 (telomeric D-loop binding)
GO:0061849 (telomeric G-quadruplex DNA binding)
GO:0098505 (G-rich strand telomeric DNA binding)
GO:1905773 (8-hydroxy-2'-deoxyguanosine DNA binding)
GO:1990955 (G-rich single-stranded DNA binding)
GO Biological Process GO:0000723 (telomere maintenance)
GO:0007004 (telomere maintenance via telomerase)
GO:0016233 (telomere capping)
GO:0032202 (telomere assembly)
GO:0032210 (regulation of telomere maintenance via telomerase)
GO:0032211 (negative regulation of telomere maintenance via telomerase)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0032508 (DNA duplex unwinding)
GO:0051096 (positive regulation of helicase activity)
GO:0051973 (positive regulation of telomerase activity)
GO:0051974 (negative regulation of telomerase activity)
GO:0060383 (positive regulation of DNA strand elongation)
GO:0061820 (telomeric D-loop disassembly)
GO:0070200 (establishment of protein localization to telomere)
GO:1905774 (regulation of DNA helicase activity)
GO:1905776 (positive regulation of DNA helicase activity)
Wikipedia POT1

Target Cross References - Protein

canSAR Q9NUX5
Human Protein Atlas ENSG00000128513
IntAct Q9NUX5
Open Targets ENSG00000128513
PharmGKB PA134934904
Reactome R-HSA-1221632 (Meiotic synapsis.)
R-HSA-171306 (Packaging Of Telomere Ends.)
R-HSA-2559586 (DNA Damage/Telomere Stress Induced Senescence.)
UniProt O95018 Q5MJ36 Q9H662 Q9NUX5 Q9NW19 Q9UG95

Target Cross References - Domain

InterPro IPR011564 (Telomer_end-bd_POT1/Cdc13.)
IPR012340 (NA-bd_OB-fold.)
IPR028389 (POT1.)
IPR032042 (POT1PC.)
Pfam PF02765 (POT1)
PF16686 (POT1PC)

Target Cross References - Structure

PDBe 1XJV 3KJO 3KJP 5H65 5UN7
CREDO 1XJV 3KJO 3KJP 5H65 5UN7
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