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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5903
Target Type SINGLE PROTEIN
Preferred Name Activin receptor type-1
Synonyms ACTR-I | ACVR1 | ACVRLK2 | ALK-2 | Activin receptor type I | Activin receptor type-1 | Activin receptor-like kinase 2 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr1

Target Components

Component Description Relationship Accession
Activin receptor type-1 SINGLE PROTEIN Q04771

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115170
Ensembl ENSG00000115170
GO Cellular Component GO:0048179 (activin receptor complex)
GO Molecular Function GO:0005524 (ATP binding)
GO:0042803 (protein homodimerization activity)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0048184 (follistatin binding)
GO:0048185 (activin binding)
GO:0050431 (transforming growth factor beta binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0032926 (negative regulation of activin receptor signaling pathway)
GO:0043066 (negative regulation of apoptosis)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045893 (positive regulation of transcription, DNA-dependent)
Wikipedia ACVR1

Target Cross References - Protein

canSAR Q04771
CGD Fibrodysplasia ossificans progressiva
Human Protein Atlas ENSG00000115170
Guide to Pharmacology 1785 (activin A receptor, type I)
PharmGKB PA24492
UniProt Q04771

Target Cross References - Domain

InterPro IPR000333 (Activin_II/TGFBeta-II_recpt.)
IPR000472 (Activin_rcpt.)
IPR000719 (Prot_kinase_cat_dom.)
IPR003605 (TGF_beta_rcpt_GS.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF01064 (Activin_recp)
PF08515 (TGF_beta_GS)

Target Cross References - Structure

PDBe 3H9R 3MTF 3OOM 3Q4U
CREDO 3H9R 3MTF 3OOM 3Q4U
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