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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5892
Target Type SINGLE PROTEIN
Preferred Name Endothelin B receptor-like protein 2
Synonyms ETBR-LP-2 | ETBRLP2 | Endothelin B receptor-like protein 2 | G-protein coupled receptor 37-like 1 | GPR37L1 | Prosaposin receptor GPR37L1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > endothelin receptor

Target Components

Component Description Relationship Accession
Prosaposin receptor GPR37L1 SINGLE PROTEIN O60883

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170075
Ensembl ENSG00000170075
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0008528 (G-protein coupled peptide receptor activity)
GO:0036505 (prosaposin receptor activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0021940 (positive regulation of cerebellar granule cell precursor proliferation)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045665 (negative regulation of neuron differentiation)
GO:0045879 (negative regulation of smoothened signaling pathway)
GO:0048712 (negative regulation of astrocyte differentiation)
GO:1903206 (negative regulation of hydrogen peroxide-induced cell death)
Wikipedia GPR37L1

Target Cross References - Protein

Human Protein Atlas ENSG00000170075
IntAct O60883
Guide to Pharmacology 104
Open Targets ENSG00000170075
PharmGKB PA28883
Pharos O60883 (Tbio)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
UniProt B2R7M9 O60883 Q5SXP7 Q86VP7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR003909 (GPR37_orph.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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