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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5891
Target Type SINGLE PROTEIN
Preferred Name Protein arginine N-methyltransferase 3
Synonyms HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > protein methyltransferase > protein arginine methyltransferase

Target Components

Component Description Relationship Accession
Protein arginine N-methyltransferase 3 SINGLE PROTEIN O60678

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000185238
Ensembl ENSG00000185238
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005840 (ribosome)
GO Molecular Function GO:0005515 (protein binding)
GO:0008168 (methyltransferase activity)
GO:0008469 (histone-arginine N-methyltransferase activity)
GO:0016274 (protein-arginine N-methyltransferase activity)
GO:0016740 (transferase activity)
GO:0035242 (protein-arginine omega-N asymmetric methyltransferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006355 (regulation of transcription, DNA-templated)
GO:0006479 (protein methylation)
GO:0019919 (peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0032259 (methylation)
GO:0034969 (histone arginine methylation)
GO:0035246 (peptidyl-arginine N-methylation)
Wikipedia PRMT3

Target Cross References - Protein

Human Protein Atlas ENSG00000185238
IntAct O60678
Guide to Pharmacology 1254
Open Targets ENSG00000185238
PharmGKB PA29462
Reactome R-HSA-3214858 (RMTs methylate histone arginines.)
R-HSA-8876725 (Protein methylation.)
UniProt B4DUC7 O60678

Target Cross References - Domain

InterPro IPR007087 (Znf_C2H2.)
IPR025799 (Arg_MeTrfase.)
IPR029063 (SAM-dependent_MTases.)

Target Cross References - Structure

PDBe 2FYT 3SMQ 4HSG 4QQN 4RYL
CREDO 2FYT 3SMQ 4HSG 4QQN 4RYL
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