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Target Report Card

Target Name and Classification

Target ID CHEMBL5881
Preferred Name Insulin
Synonyms INS | Insulin A chain | Insulin B chain | Insulin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000254647
Ensembl ENSG00000254647
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005796 (Golgi lumen)
GO:0030133 (transport vesicle)
GO:0031904 (endosome lumen)
GO:0033116 (endoplasmic reticulum-Golgi intermediate compartment membrane)
GO:0034774 (secretory granule lumen)
GO Molecular Function GO:0002020 (protease binding)
GO:0005158 (insulin receptor binding)
GO:0005159 (insulin-like growth factor receptor binding)
GO:0005179 (hormone activity)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0002674 (negative regulation of acute inflammatory response)
GO:0005975 (carbohydrate metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006521 (regulation of cellular amino acid metabolic process)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0006953 (acute-phase response)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0010469 (regulation of receptor activity)
GO:0010628 (positive regulation of gene expression)
GO:0010750 (positive regulation of nitric oxide mediated signal transduction)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0022898 (regulation of transmembrane transporter activity)
GO:0030307 (positive regulation of cell growth)
GO:0030335 (positive regulation of cell migration)
GO:0031954 (positive regulation of protein autophosphorylation)
GO:0032148 (activation of protein kinase B activity)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032460 (negative regulation of protein oligomerization)
GO:0032880 (regulation of protein localization)
GO:0033861 (negative regulation of NAD(P)H oxidase activity)
GO:0042060 (wound healing)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042593 (glucose homeostasis)
GO:0043410 (positive regulation of MAPK cascade)
GO:0044267 (cellular protein metabolic process)
GO:0045597 (positive regulation of cell differentiation)
GO:0045721 (negative regulation of gluconeogenesis)
GO:0045725 (positive regulation of glycogen biosynthetic process)
GO:0045818 (negative regulation of glycogen catabolic process)
GO:0045821 (positive regulation of glycolytic process)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0045861 (negative regulation of proteolysis)
GO:0045922 (negative regulation of fatty acid metabolic process)
GO:0046326 (positive regulation of glucose import)
GO:0046628 (positive regulation of insulin receptor signaling pathway)
GO:0046631 (alpha-beta T cell activation)
GO:0046889 (positive regulation of lipid biosynthetic process)
GO:0048167 (regulation of synaptic plasticity)
GO:0050708 (regulation of protein secretion)
GO:0050709 (negative regulation of protein secretion)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050890 (cognition)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055089 (fatty acid homeostasis)
GO:0060266 (negative regulation of respiratory burst involved in inflammatory response)
GO:0060267 (positive regulation of respiratory burst)
GO:0090277 (positive regulation of peptide hormone secretion)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0097755 (positive regulation of blood vessel diameter)
GO:0097756 (negative regulation of blood vessel diameter)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1902176 (negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)
GO:1902952 (positive regulation of dendritic spine maintenance)
GO:1903076 (regulation of protein localization to plasma membrane)
GO:1903427 (negative regulation of reactive oxygen species biosynthetic process)
GO:1990535 (neuron projection maintenance)
GO:2000252 (negative regulation of feeding behavior)
GO:2001275 (positive regulation of glucose import in response to insulin stimulus)
Wikipedia Insulin

Target Cross References - Protein

canSAR P01308
CGD Diabetes mellitus, permanent neonatal
Human Protein Atlas ENSG00000254647
IntAct P01308
Open Targets ENSG00000254647
PharmGKB PA201
Reactome R-HSA-210745 (Regulation of gene expression in beta cells.)
R-HSA-264876 (Insulin processing.)
R-HSA-422085 (Synthesis, secretion, and deacylation of Ghrelin.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-6807878 (COPI-mediated anterograde transport.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-74713 (IRS activation.)
R-HSA-74749 (Signal attenuation.)
R-HSA-74751 (Insulin receptor signalling cascade.)
R-HSA-74752 (Signaling by Insulin receptor.)
R-HSA-77387 (Insulin receptor recycling.)
R-HSA-977225 (Amyloid fiber formation.)
UniProt P01308 Q5EEX2

Target Cross References - Domain

InterPro IPR004825 (Insulin.)
IPR016179 (Insulin-like.)
IPR022352 (Insulin_family.)
IPR022353 (Insulin_CS.)
IPR036438 (Insulin-like_sf.)
Pfam PF00049 (Insulin)

Target Cross References - Structure

PDBe 1B9E 1BEN 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HTV 1J73 1JCA 1JK8 1LPH 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1TRZ More...
CREDO 1B9E 1BEN 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HTV 1J73 1JCA 1JK8 1LPH 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1TRZ More...