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Target Report Card

Target Name and Classification

Target ID CHEMBL5880
Preferred Name Interleukin-2
Synonyms IL-2 | IL2 | INN=Aldesleukin | Interleukin-2 | T-cell growth factor | TCGF
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Interleukin-2 SINGLE PROTEIN P60568

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109471
Ensembl ENSG00000109471
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005623 (cell)
GO Molecular Function GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005125 (cytokine activity)
GO:0005134 (interleukin-2 receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0019209 (kinase activator activity)
GO:0030246 (carbohydrate binding)
GO:0031851 (kappa-type opioid receptor binding)
GO:0043208 (glycosphingolipid binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002250 (adaptive immune response)
GO:0002366 (leukocyte activation involved in immune response)
GO:0002376 (immune system process)
GO:0002903 (negative regulation of B cell apoptotic process)
GO:0006955 (immune response)
GO:0007155 (cell adhesion)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0008284 (positive regulation of cell proliferation)
GO:0010469 (regulation of receptor activity)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030101 (natural killer cell activation)
GO:0030217 (T cell differentiation)
GO:0030307 (positive regulation of cell growth)
GO:0030890 (positive regulation of B cell proliferation)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032740 (positive regulation of interleukin-17 production)
GO:0034105 (positive regulation of tissue remodeling)
GO:0038110 (interleukin-2-mediated signaling pathway)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042104 (positive regulation of activated T cell proliferation)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0043066 (negative regulation of apoptotic process)
GO:0045471 (response to ethanol)
GO:0045582 (positive regulation of T cell differentiation)
GO:0045589 (regulation of regulatory T cell differentiation)
GO:0045591 (positive regulation of regulatory T cell differentiation)
GO:0045822 (negative regulation of heart contraction)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046013 (regulation of T cell homeostatic proliferation)
GO:0048304 (positive regulation of isotype switching to IgG isotypes)
GO:0050672 (negative regulation of lymphocyte proliferation)
GO:0050728 (negative regulation of inflammatory response)
GO:0050729 (positive regulation of inflammatory response)
GO:0051024 (positive regulation of immunoglobulin secretion)
GO:0060999 (positive regulation of dendritic spine development)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:2000320 (negative regulation of T-helper 17 cell differentiation)
Wikipedia Interleukin_2

Target Cross References - Protein

canSAR P60568
Human Protein Atlas ENSG00000109471
IntAct P60568
Open Targets ENSG00000109471
PharmGKB PA195
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-8877330 (RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs).)
R-HSA-9020558 (Interleukin-2 signaling.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
UniProt P01585 P60568

Target Cross References - Domain

InterPro IPR000779 (IL-2.)
IPR009079 (4_helix_cytokine-like_core.)
IPR030477 (IL-2_CS.)
Pfam PF00715 (IL2)

Target Cross References - Structure

PDBe 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E
CREDO 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E