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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5880
Preferred Name Interleukin-2
Synonyms IL-2 | IL2 | INN=Aldesleukin | Interleukin-2 | T-cell growth factor | TCGF
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Interleukin-2 SINGLE PROTEIN P60568

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109471
Ensembl ENSG00000109471
GO Cellular Component GO:0005615 (extracellular space)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0005134 (interleukin-2 receptor binding)
GO:0008083 (growth factor activity)
GO:0019209 (kinase activator activity)
GO Biological Process GO:0002903 (negative regulation of B cell apoptosis)
GO:0006916 (anti-apoptosis)
GO:0006955 (immune response)
GO:0007155 (cell adhesion)
GO:0007267 (cell-cell signaling)
GO:0030101 (natural killer cell activation)
GO:0030217 (T cell differentiation)
GO:0030307 (positive regulation of cell growth)
GO:0030890 (positive regulation of B cell proliferation)
GO:0032740 (positive regulation of interleukin-17 production)
GO:0042104 (positive regulation of activated T cell proliferation)
GO:0042523 (positive regulation of tyrosine phosphorylation of Stat5 protein)
Wikipedia Interleukin_2

Target Cross References - Protein

canSAR P60568
Human Protein Atlas ENSG00000109471
PharmGKB PA195
Reactome REACT_6900 (Signaling in Immune system.)
UniProt P01585 P60568

Target Cross References - Domain

InterPro IPR000779 (Interleukin-2.)
IPR009079 (4_helix_cytokine-like_core.)
IPR012351 (4_helix_cytokine_core.)
Pfam PF00715 (IL2)

Target Cross References - Structure

PDBe 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK
CREDO 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK