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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5877
Target Type SINGLE PROTEIN
Preferred Name Beta-hexosaminidase subunit beta
Synonyms Beta-N-acetylhexosaminidase subunit beta | Beta-hexosaminidase subunit beta chain A | Beta-hexosaminidase subunit beta chain B | Beta-hexosaminidase subunit beta | Cervical cancer proto-oncogene 7 protein | HCC-7 | HEXB | Hexosaminidase subunit B | N-acetyl-beta-glucosaminidase subunit beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Beta-hexosaminidase subunit beta SINGLE PROTEIN P07686

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038485 Beta-N-acetyl-D-hexosaminidase-A/B PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000049860
Ensembl ENSG00000049860
GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005764 (lysosome)
GO:0016020 (membrane)
GO:0042582 (azurophil granule)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0004563 (beta-N-acetylhexosaminidase activity)
GO:0008375 (acetylglucosaminyltransferase activity)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001501 (skeletal system development)
GO:0005975 (carbohydrate metabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0006689 (ganglioside catabolic process)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007040 (lysosome organization)
GO:0007338 (single fertilization)
GO:0007341 (penetration of zona pellucida)
GO:0007605 (sensory perception of sound)
GO:0007626 (locomotory behavior)
GO:0008049 (male courtship behavior)
GO:0008152 (metabolic process)
GO:0008360 (regulation of cell shape)
GO:0008654 (phospholipid biosynthetic process)
GO:0009313 (oligosaccharide catabolic process)
GO:0019915 (lipid storage)
GO:0019953 (sexual reproduction)
GO:0030203 (glycosaminoglycan metabolic process)
GO:0030207 (chondroitin sulfate catabolic process)
GO:0030214 (hyaluronan catabolic process)
GO:0031323 (regulation of cellular metabolic process)
GO:0042340 (keratan sulfate catabolic process)
GO:0042552 (myelination)
GO:0043615 (astrocyte cell migration)
GO:0044267 (cellular protein metabolic process)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048477 (oogenesis)
GO:0050885 (neuromuscular process controlling balance)
GO:0050905 (neuromuscular process)
Wikipedia HEXB

Target Cross References - Protein

canSAR P07686
CGD Sandhoff disease
Human Protein Atlas ENSG00000049860
IntAct P07686
Open Targets ENSG00000049860
PharmGKB PA29257
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-2022857 (Keratan sulfate degradation.)
R-HSA-2024101 (CS/DS degradation.)
R-HSA-2160916 (Hyaluronan uptake and degradation.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt P07686

Target Cross References - Domain

InterPro IPR013781 (Glyco_hydro_catalytic_dom.)
IPR015883 (Glyco_hydro_20_cat.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR025705 (Beta_hexosaminidase_sua/sub.)
IPR029018 (Chitobiase/Hex_dom_2-like.)
IPR029019 (HEX_eukaryotic_N.)
Pfam PF00728 (Glyco_hydro_20)
PF14845 (Glycohydro_20b2)

Target Cross References - Structure

PDBe 1NOU 1NOW 1NP0 1O7A 2GJX 2GK1 3LMY 5BRO
CREDO 1NOU 1NOW 1NP0 1O7A 2GJX 2GK1 3LMY 5BRO
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